UMIN試験ID | UMIN000019852 |
---|---|
受付番号 | R000022932 |
科学的試験名 | ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクに関する検討 |
一般公開日(本登録希望日) | 2015/11/19 |
最終更新日 | 2020/05/22 21:55:32 |
日本語
ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクに関する検討
英語
Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
日本語
ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクに関する検討
英語
Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of ADH1B and ALDH2.
日本語
ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクに関する検討
英語
Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
日本語
ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクに関する検討
英語
Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of ADH1B and ALDH2.
日本/Japan |
日本語
食道癌および頭頸部癌
英語
squamous cell carcinoma of the esophagus and the head and neck
消化器内科学(消化管)/Gastroenterology |
悪性腫瘍/Malignancy
いいえ/NO
日本語
ADH1B / ALDH2遺伝子型による食道がんEMR/ESD後の異時性食道がん、異時性頭頸部がんの発症リスクを明らかにすることを目的とする。
英語
Evaluation of the risk of metachronous squamous cell carcinoma of the esophagus and the head and neck after endoscopic resection for squamous cell carcinoma of the esophagus according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
有効性/Efficacy
日本語
英語
日本語
ADH1B / ALDH2遺伝子型ごとの異時性食道がん、異時性頭頸部がんの発症率
英語
The incidence of metachronous squamous cell carcinoma of the esophagus and the head and neck according to genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2.
日本語
英語
介入/Interventional
単群/Single arm
非ランダム化/Non-randomized
オープン/Open -no one is blinded
無対照/Uncontrolled
1
診断/Diagnosis
その他/Other |
日本語
全例で唾液を採取。
英語
It collected the saliva in all cases.
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
20 | 歳/years-old | 以上/<= |
適用なし/Not applicable |
男女両方/Male and Female
日本語
①唾液摂取が可能であること
②本研究への参加にあたり十分な説明を受けた後、十分な理解の上、研究対象者本人の自由意思による同意が得られた者
英語
1 It is possible to take a saliva.
2 Written informed consent was obtained from all patients.
日本語
①外科手術が追加された患者
②研究責任者が被験者として不適当と判断した患者
③未成年(20歳未満)の患者
④妊娠中の患者
英語
1 Surgery was added.
2 Officer has determined to be inappropriate.
3 Less than 20 years old.
4 During pregnancy.
300
日本語
名 | 勇一 |
ミドルネーム | |
姓 | 清水 |
英語
名 | Yuichi |
ミドルネーム | |
姓 | Shimizu |
日本語
北海道大学大学院 医学研究科
英語
Hokkaido University Graduate School of Medicine
日本語
消化器内科学分野
英語
Department of Gastroenterology
060-8638
日本語
札幌市北区北14条西5丁目
英語
kita 14 jyou nishi 5 chome, kitaku, Sapporo
011-716-1161
abiko1982@gmail.com
日本語
名 | 怜史 |
ミドルネーム | |
姓 | 安孫子 |
英語
名 | Satoshi |
ミドルネーム | |
姓 | Abiko |
日本語
北海道大学(大学院)
英語
Hokkaido University Graduate School of Medicine
日本語
光学医療診療部
英語
Department of Gastroenterology
060-8638
日本語
北海道札幌市北区北14条西5丁目北海道大学病院
英語
kita 14 jyou nishi 5 chome, kitaku, Sapporo
011-716-1161
abiko1982@gmail.com
日本語
その他
英語
Hokkaido University Graduate School of Medicine
日本語
北海道大学
日本語
日本語
英語
日本語
無し
英語
None
日本語
なし
日本語
自己調達/Self funding
日本語
英語
日本語
英語
日本語
英語
日本語
Hokkaido University Graduate School of Medicine
英語
Hokkaido University Graduate School of Medicine
日本語
kita 14 jyou nishi 5 chome, kitaku, Sapporo
英語
kita 14 jyou nishi 5 chome, kitaku, Sapporo
011-716-1161
abiko1982@gmail.com
いいえ/NO
日本語
英語
日本語
英語
2015 | 年 | 11 | 月 | 19 | 日 |
https://pubmed.ncbi.nlm.nih.gov/29423536/?from_term=abiko+S+hokudai&from_pos=2
最終結果が公表されている/Published
https://pubmed.ncbi.nlm.nih.gov/29423536/?from_term=abiko+S+hokudai&from_pos=2
158
日本語
Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC.
英語
Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC.
2020 | 年 | 05 | 月 | 22 | 日 |
日本語
英語
日本語
Background: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits.
英語
Background: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits.
日本語
Methods: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented.
英語
Methods: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented.
日本語
no
英語
no
日本語
Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively.
英語
Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively.
日本語
英語
日本語
英語
試験終了/Completed
2015 | 年 | 08 | 月 | 01 | 日 |
2016 | 年 | 07 | 月 | 01 | 日 |
2015 | 年 | 11 | 月 | 19 | 日 |
2016 | 年 | 09 | 月 | 01 | 日 |
2016 | 年 | 12 | 月 | 01 | 日 |
日本語
新たに採取される検体を用いた探索的研究
英語
Exploratory studies using new specimens
2015 | 年 | 11 | 月 | 18 | 日 |
2020 | 年 | 05 | 月 | 22 | 日 |
日本語
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000022932
英語
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022932
研究計画書 | |
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登録日時 | ファイル名 |
研究症例データ仕様書 | |
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登録日時 | ファイル名 |
研究症例データ | |
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登録日時 | ファイル名 |
2018/05/31 | JG完成品10.1007_s00535-018-1441-7.pdf |