UMIN試験ID | UMIN000039866 |
---|---|
受付番号 | R000045464 |
科学的試験名 | フレイルが限局性前立腺癌の治療選択に与える影響についての研究(FRART-PC study) |
一般公開日(本登録希望日) | 2020/03/19 |
最終更新日 | 2022/12/06 12:21:51 |
日本語
フレイルが限局性前立腺癌の治療選択に与える影響についての研究(FRART-PC study)
英語
The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study)
日本語
フレイルが限局性前立腺癌の治療選択に与える影響についての研究(FRART-PC study)
英語
The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study)
日本語
フレイルが限局性前立腺癌の治療選択に与える影響についての研究(FRART-PC study)
英語
The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study)
日本語
フレイルが限局性前立腺癌の治療選択に与える影響についての研究(FRART-PC study)
英語
The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study)
日本/Japan |
日本語
限局性前立腺癌
英語
localized prostate cancer
泌尿器科学/Urology |
悪性腫瘍/Malignancy
いいえ/NO
日本語
To assess the effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer
英語
To assess the effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer
安全性・有効性/Safety,Efficacy
日本語
英語
日本語
Primary outcomes: The difference of frailty between radical prostatectomy and radiation therapy in patients with localized prostate cancer.
英語
Primary outcomes: The difference of frailty between radical prostatectomy and radiation therapy in patients with localized prostate cancer.
日本語
Secondary outcomes: The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer
英語
Secondary outcomes: The effect of frailty on safety and oncological outcomes between the radical prostatectomy and radiation therapy in patients with localized prostate cancer
観察/Observational
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
日本語
英語
20 | 歳/years-old | 以上/<= |
100 | 歳/years-old | 未満/> |
男/Male
日本語
Localized prostate cancer (PC) patients who underwent robotic-radical prostatectomy (RARP)/open prostatectomy or radiatuon therapy
英語
Localized prostate cancer (PC) patients who underwent robotic-radical prostatectomy (RARP)/open prostatectomy or radiatuon therapy
日本語
Metastatic disease, no definitive therapy
英語
Metastatic disease, no definitive therapy
400
日本語
名 | Shingo |
ミドルネーム | |
姓 | Hatakeyama |
英語
名 | Shingo |
ミドルネーム | |
姓 | Hatakeyama |
日本語
Dept. of Urology, Hirosaki University Graduate School of Medicine
英語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
Urology
英語
Urology
036-8562
日本語
5 Zaifu-chou
英語
Hirosaki
0172395091
shingorilla2@gmail.com
日本語
名 | Shingo |
ミドルネーム | |
姓 | Hatakeyama |
英語
名 | Shingo |
ミドルネーム | |
姓 | Hatakeyama |
日本語
Dept. of Urology, Hirosaki University Graduate School of Medicine
英語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
Urology
英語
Urology
036-8562
日本語
5 Zaifu-chou
英語
Hirosaki
0172395091
shingorilla2@gmail.com
日本語
弘前大学
英語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
日本語
英語
日本語
弘前大学
英語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
その他の国の官庁/Government offices of other countries
日本語
日本
英語
日本語
英語
日本語
英語
日本語
Dept. of Urology, Hirosaki University Graduate School of Medicine
英語
Dept. of Urology, Hirosaki University Graduate School of Medicine
日本語
5 Zaifu-chou
英語
Hirosaki
+81172395091
rinri@hirosaki-u.ac.jp
いいえ/NO
日本語
英語
日本語
英語
2020 | 年 | 03 | 月 | 19 | 日 |
https://pubmed.ncbi.nlm.nih.gov/32684512/
未公表/Unpublished
https://pubmed.ncbi.nlm.nih.gov/32684512/
479
日本語
The G8 score and comorbidities have a significant effect on surgical contraindication in patients with localized CaP.
英語
The G8 score and comorbidities have a significant effect on surgical contraindication in patients with localized CaP.
2022 | 年 | 12 | 月 | 06 | 日 |
日本語
英語
日本語
To determine how frailty and comorbidities affect surgical contraindication in patients with localized prostate cancer (CaP).
英語
To determine how frailty and comorbidities affect surgical contraindication in patients with localized prostate cancer (CaP).
日本語
We evaluated the effects of frailty in 479 patients with localized CaP who were treated with robot-assisted radical prostatectomy (RARP), or radiotherapy (RT) eligible for surgery (RT-nonfrail), or those with RT ineligible for surgery due to frailty or comorbidity (RT-frail) from February 2017 to April 2020.
英語
We evaluated the effects of frailty in 479 patients with localized CaP who were treated with robot-assisted radical prostatectomy (RARP), or radiotherapy (RT) eligible for surgery (RT-nonfrail), or those with RT ineligible for surgery due to frailty or comorbidity (RT-frail) from February 2017 to April 2020.
日本語
none
英語
none
日本語
We retrospectively compared the geriatric 8 screening (G8) scores between patients with surgical indications (RARP and RT-nonfrail groups) and those with surgical contraindications (RT-frail group). The effect of G8 score in the RT-frail groups was investigated using multivariate logistic regression analysis. We developed and validated a nomogram for surgical contraindication in patients with localized CaP.
英語
We retrospectively compared the geriatric 8 screening (G8) scores between patients with surgical indications (RARP and RT-nonfrail groups) and those with surgical contraindications (RT-frail group). The effect of G8 score in the RT-frail groups was investigated using multivariate logistic regression analysis. We developed and validated a nomogram for surgical contraindication in patients with localized CaP.
日本語
英語
日本語
英語
試験終了/Completed
2017 | 年 | 01 | 月 | 06 | 日 |
2017 | 年 | 01 | 月 | 06 | 日 |
2017 | 年 | 01 | 月 | 07 | 日 |
2022 | 年 | 12 | 月 | 31 | 日 |
日本語
This study is a part of our prospective observational study (UMIN000025057). We planned to assess the intra-group difference of frailty among the patients with prostate cancer (PC), renal cell carcinoma (RCC), and urothelial carcinoma (UC) after the development of the CGA tool.
In the UC cohort, we planned to evaluate 1) the intra-group difference of frailty among the different stages and treatments, the effect of frailty on safety and oncological outcomes 2) between the radical cystectomy and trimodal therapy in patients with MIBC (FRART-UC study), 3) between the neobladder and non-neobladder in patients with MIBC (FRAUD study), 4) in patients with upper tract urothelial carcinoma (FRAUT study), 5) metastatic urothelial carcinoma who underwent systemic chemotherapy and/or immunotherapy (FRAM-UC study), and 6) the association of baseline frailty and quality of life (FRAQ-UC study).
In the PC cohort, we planned to evaluate 1) the inter-group difference of frailty among the different stages and treatments (FRAPC study), the effect of frailty on safety and oncological outcomes 2) between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study), 3) among the patients with metastatic PC (FRAM-PC study), 4) the association of baseline frailty and quality of life (FRAQ-PC study), and 5) the association of baseline frailty and postoperative pain (FRAP study).
In the RCC cohort, we planned to evaluate 1) the inter-group difference of frailty among the different stages and treatments, the effect of frailty on safety and oncological outcomes 2) in the patients with radical or partial nephrectomy (FRARN study), 2) between in the mRCC patients with molecular targeted therapy and/or immunotherapy(FRARMT study), and 4) the association of baseline frailty and quality of life (FRAQ-RCC). Also, we planned to estimate the gap between chronological and biological age using frailty (FRAGE-GAP study).
英語
This study is a part of our prospective observational study (UMIN000025057). We planned to assess the intra-group difference of frailty among the patients with prostate cancer (PC), renal cell carcinoma (RCC), and urothelial carcinoma (UC) after the development of the CGA tool.
In the UC cohort, we planned to evaluate 1) the intra-group difference of frailty among the different stages and treatments, the effect of frailty on safety and oncological outcomes 2) between the radical cystectomy and trimodal therapy in patients with MIBC (FRART-UC study), 3) between the neobladder and non-neobladder in patients with MIBC (FRAUD study), 4) in patients with upper tract urothelial carcinoma (FRAUT study), 5) metastatic urothelial carcinoma who underwent systemic chemotherapy and/or immunotherapy (FRAM-UC study), and 6) the association of baseline frailty and quality of life (FRAQ-UC study).
In the PC cohort, we planned to evaluate 1) the inter-group difference of frailty among the different stages and treatments (FRAPC study), the effect of frailty on safety and oncological outcomes 2) between the radical prostatectomy and radiation therapy in patients with localized prostate cancer (FRART-PC study), 3) among the patients with metastatic PC (FRAM-PC study), 4) the association of baseline frailty and quality of life (FRAQ-PC study), and 5) the association of baseline frailty and postoperative pain (FRAP study).
In the RCC cohort, we planned to evaluate 1) the inter-group difference of frailty among the different stages and treatments, the effect of frailty on safety and oncological outcomes 2) in the patients with radical or partial nephrectomy (FRARN study), 2) between in the mRCC patients with molecular targeted therapy and/or immunotherapy(FRARMT study), and 4) the association of baseline frailty and quality of life (FRAQ-RCC). Also, we planned to estimate the gap between chronological and biological age using frailty (FRAGE-GAP study).
2020 | 年 | 03 | 月 | 18 | 日 |
2022 | 年 | 12 | 月 | 06 | 日 |
日本語
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000045464
英語
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045464
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