Unique ID issued by UMIN | UMIN000000581 |
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Receipt number | R000000705 |
Scientific Title | An Open-label Controlled Trial to Assess the Prophylactic Efficacy of N-Acetylcysteine on Radio-contrast Induced Nephropathy in Patients With Advanced Chronic Kidney Disease Planned to Start Dialysis Therapy |
Date of disclosure of the study information | 2007/02/01 |
Last modified on | 2007/01/24 19:17:14 |
An Open-label Controlled Trial to Assess the Prophylactic Efficacy of N-Acetylcysteine on Radio-contrast Induced Nephropathy in Patients With Advanced Chronic Kidney Disease Planned to Start Dialysis Therapy
Prophylactic Efficacy of N-Acetylcysteine(NAC) on Radio-contrast Induced Nephropathy(RCIN) in Patients With Advanced Chronic Kidney Disease(CKD) Planned to Start Dialysis Therapy
An Open-label Controlled Trial to Assess the Prophylactic Efficacy of N-Acetylcysteine on Radio-contrast Induced Nephropathy in Patients With Advanced Chronic Kidney Disease Planned to Start Dialysis Therapy
Prophylactic Efficacy of N-Acetylcysteine(NAC) on Radio-contrast Induced Nephropathy(RCIN) in Patients With Advanced Chronic Kidney Disease(CKD) Planned to Start Dialysis Therapy
Japan |
Patients with advanced CKD planned to dialysis therapy
Nephrology | Radiology |
Others
NO
The aim of this study is to determine the prophylactic efficacy of N-acetylcysteine on radio-contrast induced nephropathy associated with coronary angiography or contrast-enhanced computed tomography in patients with advanced CKD planned to dialysis therapy
Efficacy
Confirmatory
Pragmatic
Not applicable
Change in creatinine clearance, serum creatinine and urine volume during two weeks after radio-contrast agent administration
Change in residual renal function after induction of dialysis therapy
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
No treatment
NO
NO
Pseudo-randomization
2
Prevention
Medicine |
Oral administration of N-Acetylcysteine
Saline infusion at a rate of 1 ml/kg/hour for 12 hours before and after radiocontrast agent administration
20 | years-old | <= |
85 | years-old | > |
Male and Female
Inpatients planned to start dialysis therapy and to be examined by coronary angiography or radiocontrast-enhanced computed tomography
1)Contraindicated to radiocontrast agent or N-Acetylcysteine
2)Malignancy
3)Congestive heart failure(NYHA III, IV)
4)Acute myocardial infarction, pulmonary embolism and cerebral infarction within 6 months
5)Diastolic blood pressure of 100 mmHg or more
40
1st name | |
Middle name | |
Last name | Terumasa Hayashi |
Rinku General Medical Center
Izumisano Municipal Hospital
Department of Nephrology
2-23 Rinku-Orai Kita, Izumisano, Osaka
072-469-3111
1st name | |
Middle name | |
Last name | Terumasa Hayashi |
Rinku General Medical Center, Izumisano Municipal Hospital
Department of Nephrology
2-23 Rinku-Orai Kita, Izumisano, Osaka
072-469-3111
t-hayashi@rgmc.izumisano.osaka.jp
Department of Nephrology, Rinku General Medical Center Izumisano Municipal Hospital
None
Self funding
NO
2007 | Year | 02 | Month | 01 | Day |
Unpublished
2006 | Year | 12 | Month | 19 | Day |
2007 | Year | 02 | Month | 01 | Day |
2009 | Year | 02 | Month | 01 | Day |
2007 | Year | 01 | Month | 24 | Day |
2007 | Year | 01 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000000705
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