Unique ID issued by UMIN | UMIN000000789 |
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Receipt number | R000000946 |
Scientific Title | Antiremodeling effect of leukotriene receptor antagonist (pranlukast) in asthmatic subjects with chronic airflow limitation as assessed with computed tomography (CT). |
Date of disclosure of the study information | 2007/08/10 |
Last modified on | 2008/02/06 17:13:31 |
Antiremodeling effect of leukotriene receptor antagonist (pranlukast) in asthmatic subjects with chronic airflow limitation as assessed with computed tomography (CT).
Antiremodeling effect of leukotriene receptor antagonist in asthmatic subjects.
Antiremodeling effect of leukotriene receptor antagonist (pranlukast) in asthmatic subjects with chronic airflow limitation as assessed with computed tomography (CT).
Antiremodeling effect of leukotriene receptor antagonist in asthmatic subjects.
Japan |
asthma
Pneumology |
Others
YES
To investigate antiremodeling effect of leukotriene receptor antagonist in asthmatic patients.
Efficacy
Confirmatory
Not applicable
Bronchial wall thickness, mean lung density, % low attenuation area
Pulmonary function tests
Sputum eosinophil count
Exhaled NO level
Procollagen type 1 terminal peptide of sputum supernatant
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Treatment with pranlukast 450 mg for 24 weeks
20 | years-old | <= |
Not applicable |
Male and Female
Perennial asthmatic patients visiting our outpatient clinic, who have been treated with inhaled corticosteroid and are stable for at least 6 months with FEV1<80% or FEV1/FVC<70% or %MMF<70% after inhalation of 200 mcg of salbutamol, and are never- or non-current nonsmokers with a smoking history of <5 pack-years, and were never treated with leukotriene receptor antagonists.
Subjects who suffered from respiratory tract infection in the previous month.
Subjects who were taking NSAIDs.
30
1st name | |
Middle name | |
Last name | Akio Niimi |
Kyoto University
Department of Respiratory Medicine
54 Kawahara, Shyogoin, Sakyo-ku, Kyoto
075-751-3830
1st name | |
Middle name | |
Last name | Hirofumi Matsuoka |
Kyoto University Hospital
Department of Respiratory Medicine
54 Kawahara, Shyogoin, Sakyo-ku, Kyoto
075-751-3830
Kyoto University Hospitaly
Kyoto University Graduate School of Medicine
Self funding
NO
2007 | Year | 08 | Month | 10 | Day |
Unpublished
No longer recruiting
2004 | Year | 12 | Month | 20 | Day |
2005 | Year | 06 | Month | 01 | Day |
2007 | Year | 09 | Month | 01 | Day |
2007 | Year | 09 | Month | 01 | Day |
2007 | Year | 09 | Month | 01 | Day |
2007 | Year | 12 | Month | 01 | Day |
2007 | Year | 08 | Month | 06 | Day |
2008 | Year | 02 | Month | 06 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000000946
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