Unique ID issued by UMIN | UMIN000000876 |
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Receipt number | R000000993 |
Scientific Title | Elevated Plasma Level of CD144-Positive Endothelium-Derived-Microparticles Predicts Future Cardiovascular Events in Patients at High-Risk for Coronary Artery Desease |
Date of disclosure of the study information | 2007/11/02 |
Last modified on | 2014/06/02 12:23:26 |
Elevated Plasma Level of CD144-Positive Endothelium-Derived-Microparticles Predicts Future Cardiovascular Events in Patients at High-Risk for Coronary Artery Desease
KUMAMOTO EMPs STUDY
Elevated Plasma Level of CD144-Positive Endothelium-Derived-Microparticles Predicts Future Cardiovascular Events in Patients at High-Risk for Coronary Artery Desease
KUMAMOTO EMPs STUDY
Japan |
Patients at high-risk for coronary artery disease
Cardiology |
Others
NO
Several prior studies have demonstrated that endothelial dysfunction predicts future cardiovascular events. But there are no circulating soluble markers reflect endothelial function.
In the present study, we investigated whether plasma CD144-positive EMPs levels , a novel plasma marker of endothelial dysfunction, could predict future cardiovascular events in patients at high-risk for coronary artery disease.
Efficacy
The end points were any of cardiovascular death, nonfatal myocardial infarction, unstable angina, fatal or nonfatal ischemic stroke, or coronary revascularization to new lesions.
Observational
Not applicable |
80 | years-old | >= |
Male and Female
Patients at high risk for CAD. High risk for CAD was defined as having more than 2 factors of following; age 65 years or older; current smoking; hypertension (140/90 mmHg or more, or taking any antihypertensive medications); dyslipidemia (high density lipoprotein [HDL] cholesterol less than 40mg/dl, low-density lipoprotein [LDL] cholesterol 140mg/dl or more, or triglycerides 150mg/dl or more); diabetes mellitus; body mass index (BMI) 25.0 kg/m2 or more; family history of ischemic heart disease. Patient with stable CAD or history of old myocardial infarction (OMI) were also enrolled
The exclusion criteria for the study were severe valvular heart disease requiring surgical intervention, plan for coronary revascularization, active infection, and malignant disease. Patients with ACS were also excluded because they had a significantly higher cardiovascular event ratio than that of stable CAD patients.
500
1st name | |
Middle name | |
Last name | Hisao Ogawa |
Graduate School of Medical Sciences, Kumamoto University
Department of Cardiovascular Medicine
1-1-1 Honjo Kumamoto, Kumamoto, Japan
096-373-5175
yukioga@kumamoto-u.ac.jp
1st name | |
Middle name | |
Last name | Seigo Sugiyama |
Graduate School of Medical Sciences, Kumamoto University
Department of Cardiovascular Medicine
1-1-1 Honjo Kumamoto, Kumamoto, Japan
096-373-5175
ssugiyam@kumamoto-u.ac.jp
Graduate School of Medical Sciences, Kumamoto University
Self funding
Self funding
NO
2007 | Year | 11 | Month | 02 | Day |
Published
Completed
2003 | Year | 05 | Month | 01 | Day |
2003 | Year | 05 | Month | 01 | Day |
2008 | Year | 07 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
Patients at high risk for CAD were followed up every month at the hospital until July 2008 or the occurrence of end points. The end points were any of cardiovascular death, nonfatal myocardial infarction, unstable angina, fatal or nonfatal ischemic stroke, coronary revascularization to new lesions or lower limb amputation.
2007 | Year | 11 | Month | 02 | Day |
2014 | Year | 06 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000000993
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