Unique ID issued by UMIN | UMIN000001139 |
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Receipt number | R000001383 |
Scientific Title | Japan Morning Surge-Total Organ Protection: JMS-TOP Study |
Date of disclosure of the study information | 2008/04/29 |
Last modified on | 2018/09/05 12:19:16 |
Japan Morning Surge-Total Organ Protection: JMS-TOP Study
JMS-TOP Study
Japan Morning Surge-Total Organ Protection: JMS-TOP Study
JMS-TOP Study
Japan |
Hypertension
Medicine in general | Cardiology | Endocrinology and Metabolism |
Nephrology | Geriatrics |
Others
NO
To compare the efficacy of evening versus morning administration of angiotensin II receptor blocker (Candesartan) on home blood pressure and hypertensive target organ damage
Safety,Efficacy
Not applicable
Reduction of home morning blood pressure
Improvements of hypertensive target organ damage measured as urinary albumin excretion ratio and brain-type natriuretic peptide
Changes in 24-hr blood pressure
Changes in left ventricular hypertrophy(electrocardiogram and echocardiography), left ventricular diastolic function, carotid intima-media thickness, pulse wave velocity, augmentation index and baroreflex sensitivity
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
YES
NO
Institution is not considered as adjustment factor.
YES
Central registration
2
Treatment
Medicine |
Evening administration of angiotensin II receptor blocker (Candesartan)
Morning administration of angiotensin II receptor blocker (Candesartan)
Not applicable |
Not applicable |
Male and Female
Hypertensive patients with morning and/or evening home systolic blood pressure at least 135 mmHg
1) Recent history (within 6 months) of ischemic heart disease, stroke (excluding transient ischemic attack), aortic dissection, and peripheral arterial disease.
2) History of admission due to heart failure
3) On hemodialysis
4) Chronic inflammatory disease (cancer, collagen disease)
5) Subjects who are difficult to get informed consent
6) Subjects who are unable to visit to hospitals/clinics
7) History of adverse effect with candesartan, and contraindications of candesartan
8) Atrial fibrillation
9) Bilateral renal arterial stenosis
450
1st name | |
Middle name | |
Last name | Kazuomi Kario |
Jichi Medical University
Division of Cardiovascular Medicine
Yakushiji 3311-1, Shimotsuke, Tochigi, Japan
0285-44-2111
kkario@jichi.ac.jp
1st name | |
Middle name | |
Last name | Satoshi Hoshide, Joji Ishikawa |
JMS-TOP study coordinator
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medi
Yakushiji 3311-1, Shimotsuke, Tochigi 320-0498, Japan
0285-44-2130
saikimi@jichi.ac.jp
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
Japan Heart Foundation
Non profit foundation
Japan
NO
2008 | Year | 04 | Month | 29 | Day |
Unpublished
Completed
2005 | Year | 04 | Month | 01 | Day |
2005 | Year | 04 | Month | 01 | Day |
2008 | Year | 12 | Month | 01 | Day |
2009 | Year | 06 | Month | 01 | Day |
2009 | Year | 09 | Month | 01 | Day |
2008 | Year | 04 | Month | 29 | Day |
2018 | Year | 09 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001383
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