Unique ID issued by UMIN | UMIN000001216 |
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Receipt number | R000001484 |
Scientific Title | A study of the effect of nicergoline for dysphagia in patients with aspiration pneumonia |
Date of disclosure of the study information | 2009/01/01 |
Last modified on | 2011/07/13 23:34:37 |
A study of the effect of nicergoline for dysphagia in patients with aspiration pneumonia
The effect of nicergoline in dysphagia
A study of the effect of nicergoline for dysphagia in patients with aspiration pneumonia
The effect of nicergoline in dysphagia
Japan |
Dysphagia
Pneumology |
Others
NO
To investigate the efficacy of nicergoline for dysphagia in patients with aspiration pneumonia
Efficacy
Swallowing reflex
Serum level of substance P
Recurrence of aspiration pneumonia
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
Numbered container method
2
Treatment
Medicine |
Treatment by nicergoline
Treatment by imidapril
65 | years-old | <= |
Not applicable |
Male and Female
Dysphagia patients proved by simple swallowing provocation test.
Patients with past history of pneumonia.
Patients who have signed the agreement for participation in this study.
Patients who have already taken nicergoline or imidapuril.
In addition to the above exclusion criteria, patients judged to be inadequate to participate in this study by their physician.
60
1st name | |
Middle name | |
Last name | Taku Nakashima |
Hiroshima General Hospital of West Japan Railway Company
Department of respiratory disease
3-1-36 Futabanosato, Higashi-ku, Hiroshima-city 732-0057 Japan
082-262-1171
1st name | |
Middle name | |
Last name | Taku Nakashima |
Hiroshima General Hospital of West Japan Railway Company
Department of respiratory disease
3-1-36 Futabanosato, Higashi-ku, Hiroshima-city 732-0057 Japan
082-262-1171
Department of respiratory disease, Hiroshima General Hospital of West Japan Railway Company
None
Self funding
NO
2009 | Year | 01 | Month | 01 | Day |
Published
http://www.ncbi.nlm.nih.gov/pubmed/21694649
-Significant elevations of serum substance P were obtained by both medications (nicergoline or imidapril) after 4 weeks of treatment.
-Patients whose dysphagia was improved showed significantly increased serum levels of substance P.
-There was no statistically significant difference in the overall proportion of patients who showed improvements in dysphagia and pneumonia recurrence with imidapril or nicergoline treatment.
-Nicergoline, but not imidapril, seemed to be more effective at improving dysphagia and elevating serum substance P in patients with dementia.
Completed
2008 | Year | 06 | Month | 11 | Day |
2009 | Year | 01 | Month | 01 | Day |
2009 | Year | 07 | Month | 01 | Day |
2009 | Year | 07 | Month | 01 | Day |
2009 | Year | 08 | Month | 01 | Day |
2009 | Year | 08 | Month | 01 | Day |
2008 | Year | 06 | Month | 27 | Day |
2011 | Year | 07 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001484
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