Unique ID issued by UMIN | UMIN000001293 |
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Receipt number | R000001572 |
Scientific Title | Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia |
Date of disclosure of the study information | 2008/12/01 |
Last modified on | 2009/08/09 21:19:39 |
Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia
Midazolam and electroencephalogram
Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia
Midazolam and electroencephalogram
Japan |
Patients undergoing operations under general anesthesia, not limited to specific diseases
Not applicable |
Others
NO
Adequate anesthetic level is required during general anesthesia. Although midazolam is used for induction of general anesthesia, there is few information regarding the relationships between plasma concentration of midazolam and electroencephalogram. We investigate the relationships between the plasma concentration of midazolam and electroencephalogram.
PK,PD
plasma concentration of midazolam, bispectral index, 95% spectral edge frequency
Interventional
Parallel
Randomized
Open -no one is blinded
Dose comparison
2
Diagnosis
Medicine |
After starting recoriding of electroencephalogram in the operating room, general anesthesia is induced with bolus midazolam of 0.2 mg/kg and the trachea is intubated. Blood is obtained from indwelling arterial or venous catheters 5, 10, 15, 20, 30, 45 and 60 minutes following induction of anesthesia.
After starting recoriding of electroencephalogram in the operating room, general anesthesia is induced with bolus midazolam of 0.3 mg/kg and the trachea is intubated. Blood is obtained from indwelling arterial or venous catheters 5, 10, 15, 20, 30, 45 and 60 minutes following induction of anesthesia.
20 | years-old | <= |
70 | years-old | >= |
Male and Female
Patients undergoing operations of body surface or extremities under general anesthesia
1) patients undergoing thoracotomy or lapalotomy, 2) patients with advanced hepatic or renal dysfunction, 3) taking cytochrome P4503A inducers or inhibitors preoperatively, 4) predicted difficulty in tracheal intubation, 5) receiving CYP3A inhibitors during anesthesia, 6) receiving medications affecting electroencephalogram
30
1st name | |
Middle name | |
Last name | Yutaka Oda |
Osaka City University Graduate School of Medicine
Department of Anesthesiology
1-5-7 Asahimachi, Abeno-ku, Osaka 545-8586, Japan
06-6645-2186
1st name | |
Middle name | |
Last name | Yutaka Oda |
Osaka City University Graduate School of Medicine
Department of Anesthesiology
1-5-7 Asahimachi, Abeno-ku, Osaka 545-8586, Japan
06-6645-2186
Department of Anesthesiology, Osaka City University Graduate School of Medicine
Institution or department
Self funding
NO
2008 | Year | 12 | Month | 01 | Day |
Unpublished
Plasma and simulated effect site concentrations of midazolam decreased rapidly and were significantly higher in the large-dose group than in the small-dose group (P = 0.005 and < 0.001, respectively). Both BIS and relative beta ratio decreased after induction and remained between 60 and 70, between -1.8 and -1.2, respectively. No differences were observed in BIS, relative beta ratio or 95% spectral edge frequency between the two groups, either. Relative beta ratio significantly correlated with BIS in both groups (r2 = 0.66 and 0.78, respectively, P < 0.001 for both). The electroencephalographic spectral power density in the beta- (≥13 and <30 Hz) band was significantly increased after induction, besides being significantly larger in the large-dose group than in the small-dose group (P = 0.009).
Completed
2007 | Year | 09 | Month | 01 | Day |
2007 | Year | 10 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
2008 | Year | 08 | Month | 01 | Day |
2009 | Year | 01 | Month | 01 | Day |
Submitting for publication
2008 | Year | 08 | Month | 04 | Day |
2009 | Year | 08 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001572
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