Unique ID issued by UMIN | UMIN000001418 |
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Receipt number | R000001730 |
Scientific Title | The efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma |
Date of disclosure of the study information | 2008/10/08 |
Last modified on | 2011/04/11 09:59:20 |
The efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma
Autologous gamma/delta T cell therapy for extrahepatic metastasis of hepatocellular carcinoma
The efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma
Autologous gamma/delta T cell therapy for extrahepatic metastasis of hepatocellular carcinoma
Japan |
Extrahepatic metastasis of hepatocellular carcinoma
Hepato-biliary-pancreatic surgery |
Malignancy
NO
To investigate efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma
Safety,Efficacy
Exploratory
Pragmatic
Not applicable
Progression- free survival
Overall survival
Response rate
Survival rate (1 and 2 years)
Response of tumor-related markers
Immunological responses
Safety
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Maneuver |
Gamma/delta T cells are injected on day0, day7, day14, day21, day35, day49, day63, day77.
20 | years-old | <= |
Not applicable |
Male and Female
Hepatocellular carcinoma patients who have extrahepatic metastasis:
- Pathological diagnosis of hepatocellular carcinoma;
- Diagnosis of extrahepatic metastasis by imaging;
- Life-expectancy is more than 3 months;
- Performance status is 0-1;
- No serious abnormality in heart, lung, bone marrow, liver, and renal functions.
Patients who have:
- Pulmonary fibrosis or interstitial pneumonia, including their history or predisposition of them;
- Active enteritis,
- Active autoimmune diseases,
- Active infections;
- Other cancers;
- Other serious complications;
- Continuous systemic administration of steroids.
15
1st name | |
Middle name | |
Last name | Norihiro Kokudo |
The University of Tokyo Hospital
Department of Hepatobiliary Pancreatic Surgery and Department of Artificial Organ and Transplantation Surgery
7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
03-5800-8654
1st name | |
Middle name | |
Last name | Kazuhiro Kakimi |
Graduate School of Medicine, The University of Tokyo
Department of Immunotherapeutics
7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
03-5805-3161
immunotherapy-admin@umin.ac.jp
The University of Tokyo Hospital
Medinet Co.,Ltd.
Profit organization
Japan
NO
2008 | Year | 10 | Month | 08 | Day |
Unpublished
Completed
2008 | Year | 09 | Month | 16 | Day |
2008 | Year | 09 | Month | 01 | Day |
2012 | Year | 03 | Month | 01 | Day |
2008 | Year | 10 | Month | 08 | Day |
2011 | Year | 04 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001730
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