Unique ID issued by UMIN | UMIN000001719 |
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Receipt number | R000001944 |
Scientific Title | Tokushima Anti-Oxidation Clinical Trial In hypertensives, Cilnidipine versus Amlodipine |
Date of disclosure of the study information | 2009/02/23 |
Last modified on | 2009/02/12 14:36:57 |
Tokushima Anti-Oxidation
Clinical Trial In hypertensives, Cilnidipine versus Amlodipine
TACTICAL
Tokushima Anti-Oxidation
Clinical Trial In hypertensives, Cilnidipine versus Amlodipine
TACTICAL
Japan |
hypertension
Cardiology |
Others
NO
To compare the anti-oxidation effect of cilnidipine (a dual N & L type calcium channel blocker) and amlodipine (a L type calcium channel blocker) in hypertensive patients.
Safety,Efficacy
1.Clinic blood pressure,heart rate.
2.Home blood pressure,heart rate.
3.urinary 8-OHdG.
4.hs-CRP
5.urinary albumin-creatinine ratio.
6.urinary L-FABP.
7.LDL-C,TG,HDL-C,BUN,Cr,*HbA1c*fasting blood glucose(*Patients with diabetes)
Interventional
Parallel
Randomized
Open -but assessor(s) are blinded
Active
2
Treatment
Medicine |
clinidipine (initial dose is 10mg/day, but 10-20mg is available depending on the blood pressure level)
amlodipine (initial dose is 5mg/day, but 5-10mg is available depending on the blood pressure level)
45 | years-old | <= |
75 | years-old | >= |
Male and Female
1.Out patients
2.Patients who received an Antihypertensive treatment with RAS inhibitors.
3.Blood pressure (BP):systolic BP (SBP) 140mmHg and above or diastolic BP (DBP) 90mmHg and above.
1.Malignant hypertension
2.Pregnant women,or Women suspected of being pregnant.
3.Severe liver disorder.
4.Patients who are inadequate to enter this study due to the other reasons by physician's judgments.
50
1st name | |
Middle name | |
Last name | Masataka SATA |
The University of Tokushima Institute of Health Biosciences, Graduate School
Cardiovascular Medicine
3-18-15 Kuramoto-cho,Tokushima
1st name | |
Middle name | |
Last name |
The University of Tokushima Institute of Health Biosciences, Graduate School
Cardiovascular Medicine
088-633-7852
Cardiovascular Medicine, The University of Tokushima Institute of Health Biosciences, Graduate School
None
Self funding
NO
2009 | Year | 02 | Month | 23 | Day |
Unpublished
2009 | Year | 01 | Month | 23 | Day |
2009 | Year | 02 | Month | 01 | Day |
2010 | Year | 09 | Month | 01 | Day |
2009 | Year | 02 | Month | 20 | Day |
2009 | Year | 02 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000001944
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