Unique ID issued by UMIN | UMIN000001673 |
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Receipt number | R000002021 |
Scientific Title | Role of food intolerance and effect of protease inhibitor in patients with irritable bowel syndrome (IBS) |
Date of disclosure of the study information | 2009/01/30 |
Last modified on | 2013/08/30 09:13:14 |
Role of food intolerance and effect of protease inhibitor in patients with irritable bowel syndrome (IBS)
Effect of protease inhibitor in patients with irritable bowel syndrome (IBS)
Role of food intolerance and effect of protease inhibitor in patients with irritable bowel syndrome (IBS)
Effect of protease inhibitor in patients with irritable bowel syndrome (IBS)
Japan |
Irritable bowel syndrome (IBS)
Gastroenterology | Psychosomatic Internal Medicine |
Others
NO
To confirm the hypothesis that protease inhibitor, camostat mesilate attenuates colonic hypersensitivity and hyperreactive motility and improves symptom severity in patients with IBS
Efficacy
Adequate relief (AR) at the end of the intervention
Symptom severity at the end of the intervention
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
Central registration
2
Treatment
Medicine |
Camostat mesilate 200mg (t.i.d.) will be administrated for 14 days. Rectal barostat measurements will be performed before and the end of the intervention.
Placebo (t.i.d.) will be administrated for 14 days. Rectal barostat measurements will be performed before and the end of the intervention.
20 | years-old | <= |
Not applicable |
Male and Female
Patients who met Rome III diagnostic criteria for IBS
Patients who have severe systemic/ psychological complications, and/or who have histories of any abdominal surgery except appendectomy, and/or who needs to continue any pharmacological treatment during the study
30
1st name | |
Middle name | |
Last name | Shin Fukudo, MD, PhD |
Tohoku University Graduate School of Medicine
Department of Behavioral Medicine
2-1 Seiryo, Aoba, Sendai 980-8575, Japan
1st name | |
Middle name | |
Last name | Motoyori Kanazawa, MD, PhD |
Tohoku University Graduate School of Medicine
Department of Behavioral Medicine
Tohoku University Graduate School of Medicine
Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan
Japan
NO
2009 | Year | 01 | Month | 30 | Day |
Unpublished
No longer recruiting
2008 | Year | 06 | Month | 10 | Day |
2009 | Year | 02 | Month | 01 | Day |
2012 | Year | 03 | Month | 01 | Day |
2009 | Year | 01 | Month | 30 | Day |
2013 | Year | 08 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002021
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