Unique ID issued by UMIN | UMIN000001781 |
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Receipt number | R000002143 |
Scientific Title | Refractory VT/VF, Prospective Evaluation to Differentiate Lidocaine Efficacy from Nifekalant |
Date of disclosure of the study information | 2009/03/18 |
Last modified on | 2016/08/05 22:18:38 |
Refractory VT/VF, Prospective Evaluation to Differentiate Lidocaine Efficacy from Nifekalant
RELIEF Study
Refractory VT/VF, Prospective Evaluation to Differentiate Lidocaine Efficacy from Nifekalant
RELIEF Study
Japan |
Ventricular tachycardia, Ventricular fibrillation
Cardiology | Emergency medicine | Intensive care medicine |
Others
NO
The aim of this study is to compare the efficacy and safety of nifekalant and lidocaine in patients with shock-resistant in-hospital VF/VT.
Safety,Efficacy
Confirmatory
Pragmatic
Not applicable
Termination of VT/VF with/without shock
Return of spontaneous circulation, One-month survival, Discharge alive from the hospital,
Adverse events: asystole,pulseless electrical activity, Torsades de pointes, QT prolongation(>0.55)
Observational
Not applicable |
Not applicable |
Male and Female
In-hospital sustained VT/VF resistant to at least 2 shocks
Drug-induced long QT syndrome
Congenital long QT syndrome
55
1st name | |
Middle name | |
Last name | Hiroshi Kasanuki |
Waseda University
Science and Engineering
1-7 Koji-machi, Chiyoda-ku, Tokyo 102-0083 Japan
03-5216-3001
hkasanuki@jheart.or.jp
1st name | |
Middle name | |
Last name | Tsuyoshi Shiga |
Tokyo Women's Medical University
Cardiology
8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
03-3353-8111
mshiga@hij.twmu.ac.jp
Japan Medical Promotion Agency
Japan Research Promotion Society for Cardiovascular Disease
Non profit foundation
Japan
NO
2009 | Year | 03 | Month | 18 | Day |
Published
http://www.sciencedirect.com/science/article/pii/S0300957209005036
After treatment of nifekalant, 23 of 27 patients showed termination of VF/VT, as compared with 15 of 28 patients treated with lidocaine (P=0.03) with/without additional shock.
Completed
2005 | Year | 06 | Month | 25 | Day |
2005 | Year | 07 | Month | 01 | Day |
2008 | Year | 03 | Month | 01 | Day |
2008 | Year | 10 | Month | 01 | Day |
2008 | Year | 10 | Month | 01 | Day |
2009 | Year | 02 | Month | 01 | Day |
In total, 55 patients were enrolled. After treatment of nifekalant, 22 of 27 patients showed termination of VF/VT, as compared with 15 of 28 patients treated with lidocaine (P=0.03) with/without additional shock. 23 of 27 patients with nifekalant showed return of spontanous circulation, as compared with 15 of 28 patients with lidocaine (P=0.01). There was a higher incidence of asystole and pulseless electrical activity with lidocaine (7 of 28 patients) than with nifekalant (0 of 27 patients) (P=0.005).
2009 | Year | 03 | Month | 17 | Day |
2016 | Year | 08 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002143
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