Unique ID issued by UMIN | UMIN000001802 |
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Receipt number | R000002176 |
Scientific Title | Investigation of effective treatment of nocturnal hypertension in diabetes |
Date of disclosure of the study information | 2009/07/01 |
Last modified on | 2017/04/02 02:28:01 |
Investigation of effective treatment of nocturnal hypertension in diabetes
Treatment of nocternal hypertension in diabetes with new blood pressure measureing method
Investigation of effective treatment of nocturnal hypertension in diabetes
Treatment of nocternal hypertension in diabetes with new blood pressure measureing method
Japan |
Nocturnal hypertension in type 2 DM
Endocrinology and Metabolism |
Others
NO
Effects on noucurnal hypertension with changing ARB and CCB to losartan/ hydrochlorothiazide in type 2 diabetes
Others
effects on metabolic parameter
Confirmatory
Explanatory
Phase IV
Change in nocturnal blood pressure level after 12 weeks of treatment
change in blood pressure level on an outpatient basis after 4,8 weeks of treatment
change after12 weeks about
HbA1c, fasting bllod glucose level, urine alubimin excretion, Urine Na, Crine K, renin, aldsterone, BNP, serum K, serum Na, serum UA, serum Creatinine, eGFR, LDL-C, TG, HDL-C
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
NO
NO
Institution is not considered as adjustment factor.
NO
Central registration
2
Treatment
Medicine |
Losartan / hydrochlorothiazide group
ARB and CCB group
20 | years-old | <= |
Not applicable |
Male and Female
1) Hypertensive diabetic patients, who have been treated with ARB and Carcium channnel blocker for more than 4weeks, but not reached systolic blood pressure to 150 mmHg and /or diastolic blood pressure to 100 mmHg
2) aged more than 20 years
3) men and women
4) patients who fully understand the study procedures explained to them using explanatory notes and have given written informed consent to patients in the study
1) patients with secondary hypertension
2) patients with liver dysfunction (GPT over three times the normal value)
3) patients with renal failure (serum creatinine over 2.0 mg/dL)
4) patients with bilareral renal artery stenosis
5) pregnant or possible pregnant women
6) patients with a history of hypersensitivity to Losartan or thiazide
50
1st name | |
Middle name | |
Last name | kazuhiko sakaguchi |
Kobe University Graduate School of Medicine
Division of deabetes, metabolism and endocrinology
7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan
078-382-5861
kzhkskgc@med.kobe-u.ac.jp
1st name | |
Middle name | |
Last name | kazuhiko sakaguchi |
Kobe University Graduate School of Medicine
Division of deabetes, metabolism and endocrinology
7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan
078-382-5861
kzhkskgc@med.kobe-u.ac.jp
Kobe University Graduate School of Medicine
Division of deabetes, metabolism and endocrinology
Division of deabetes, metabolism and endocrinology
Kobe University Graduate School of Medicine
NO
2009 | Year | 07 | Month | 01 | Day |
Unpublished
Terminated
2009 | Year | 05 | Month | 15 | Day |
2009 | Year | 07 | Month | 01 | Day |
2011 | Year | 03 | Month | 01 | Day |
2009 | Year | 03 | Month | 26 | Day |
2017 | Year | 04 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002176
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