Unique ID issued by UMIN | UMIN000002036 |
---|---|
Receipt number | R000002417 |
Scientific Title | Assessment of disease activity with quantitative joint power Doppler ultrasonography in patient with rheumatoid arthritis |
Date of disclosure of the study information | 2009/06/18 |
Last modified on | 2010/04/30 20:18:25 |
Assessment of disease activity with quantitative joint power Doppler ultrasonography in patient with rheumatoid arthritis
Assessment of disease activity with quantitative joint power Doppler ultrasonography in patient with rheumatoid arthritis
Assessment of disease activity with quantitative joint power Doppler ultrasonography in patient with rheumatoid arthritis
Assessment of disease activity with quantitative joint power Doppler ultrasonography in patient with rheumatoid arthritis
Japan |
Rheumatoid arthritis
Clinical immunology |
Others
NO
To investigate association between synovial vascularity determined by power Doppler ultrasonography and progression of structural joint damage
Others
Examine a relation between synovial vascularity and radiographic joint damage
Clinical and laboratory assessments are examined through study. Radiography of hands and feet are performed at baseline and 20th week. Power Doppler ultrasonography is performed at baseline and 8th week. Magnetic resonance imaging (MRI) is performed at baseline.
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patient who are satisfied the criteria below:
1) Patients who are satisfied American College of Rheumatology 1987 RA diagnostic criteria
2) Patients diagnosed as active state of RA according to DAS28-ESR (>2.7)
3) Patients are informed of this protocol and consented to participated
Patients who fulfill one of the following criteria must be excluded:
1) Patients who have apparent infection
2) Female patients who are during pregnancy or lactation
3) Patients who are judged to be inappropriate by investigator
20
1st name | |
Middle name | |
Last name | Kazuhide Tanimura |
Tokeidai Memorial Hospital
Center for Rheumatic Diseases
Kita-1, Higashi-1, Cyuo-ku, Sapporo, Hokkaido
1st name | |
Middle name | |
Last name |
Tokeidai Memorial Hospital
Center for Rheumatic Diseases
jun.fukae@ryumachi-jp.com
Center for Rheumatic Diseases, Tokeidai Memorial Hospital
None
Self funding
NO
2009 | Year | 06 | Month | 18 | Day |
Published
Results: Quantitative power Doppler ultrasonography (PDUS) was significantly correlated with enhancement rate of MRI in each single finger joint. Comparing quantitative synovial vascularity and radiographic change in single MCP or PIP joint, the level of vascularity at baseline showed significant positive correlation with radiographic progression at the 20th week. The change of vascularity responded to DMARDs, defined as the percentage change in vascularity by the 8th week from baseline, was inversely correlated with radiographic progression in each MCP joint. Quantitative PDUS method was more useful than semi-quantitative method for the evaluation of synovial vascularity in single finger joint.
Completed
2007 | Year | 11 | Month | 30 | Day |
2007 | Year | 12 | Month | 01 | Day |
2010 | Year | 01 | Month | 01 | Day |
Objective: To investigate the relation between synovial vascularity, assessed by quantitative power Doppler ultrasonography, and progression of structural damage in individual finger joint in patients with RA
Design: prospective observational study
Sampling: Patients were examined by joint imaging assessments through study
2009 | Year | 06 | Month | 03 | Day |
2010 | Year | 04 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002417
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |