Unique ID issued by UMIN | UMIN000002070 |
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Receipt number | R000002498 |
Scientific Title | Correlation between cholesterol absorption and atherogenic risk factors in hypercholesterolemic patients with type2 diabetes. |
Date of disclosure of the study information | 2009/12/31 |
Last modified on | 2010/06/14 19:49:26 |
Correlation between cholesterol absorption and atherogenic risk factors in hypercholesterolemic patients with type2 diabetes.
The efficacy of inhibiting cholesterol absorption in hypercholesterolemic patients wiht type2 diabetes
Correlation between cholesterol absorption and atherogenic risk factors in hypercholesterolemic patients with type2 diabetes.
The efficacy of inhibiting cholesterol absorption in hypercholesterolemic patients wiht type2 diabetes
Japan |
Hypercholesterolemic patients with type2 diabetes
Medicine in general | Endocrinology and Metabolism |
Others
NO
We considered that cholesterol absorption correlates with atherogenic risk factors in hypercholesterolemic patients with type2 diabetes. Furthermore, we demonstrate the efficacy of treatment with ezetimibe in these subject.
Safety,Efficacy
The efficacy of ezetimibe on LDL-cholesterol reduction.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Ezetimibe
20 | years-old | <= |
Not applicable |
Male and Female
LDL-C>120mg/dL
LDL-C<180mg/dL
patients with type2 diabetes treating over 4weeks
HbA1c>10.0% or increasing or decreasing over 2% on HbA1c during past 3months
patients with serious hepatic dysfunction
Serum creatinine>2.0mg/dL
Familyal hypercholesterolemia
Pregnancy or Lactation
120
1st name | |
Middle name | |
Last name | Yasuhiko, Iwamoto |
Tokyo Women's Medical University
Diabetes center
8-1, Kawada-cho, Shinzyuku-ku, Tokyo, 162-8666 Japan
1st name | |
Middle name | |
Last name |
Tokyo Women's Medical University
Diabetes canter
8-1, Kawada-cho, Shinzyuku-ku, Tokyo, 162-8666 Japan
03-3353-8111
Diabetes canter, Tokyo women's medical university
None
Other
NO
2009 | Year | 12 | Month | 31 | Day |
Partially published
1) Increased cholesterol absorption markers in patients with statin treatment or patients with microvascular complicatoin.
2) Serum lipid prfiles significantlly improved after ezetimibe treatment.
3) Cholesterol absorption markers decreased with ezetimibe treatment.
Completed
2008 | Year | 09 | Month | 01 | Day |
2008 | Year | 10 | Month | 01 | Day |
2009 | Year | 10 | Month | 01 | Day |
2010 | Year | 10 | Month | 01 | Day |
2010 | Year | 11 | Month | 01 | Day |
2009 | Year | 06 | Month | 12 | Day |
2010 | Year | 06 | Month | 14 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002498
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