Unique ID issued by UMIN | UMIN000002145 |
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Receipt number | R000002623 |
Scientific Title | Randomized controlled trial on an effect of preparation of botanical extract on physiological halitosis. |
Date of disclosure of the study information | 2009/08/01 |
Last modified on | 2010/02/16 17:24:47 |
Randomized controlled trial on an effect of preparation of botanical extract on physiological halitosis.
Effect of preparation of botanical extract on physiological halitosis.
Randomized controlled trial on an effect of preparation of botanical extract on physiological halitosis.
Effect of preparation of botanical extract on physiological halitosis.
Japan |
Physiological halitosis
Dental medicine |
Others
NO
This study evaluates the long-term effect of preparation of botanical extract on physiological halitosis in a randomized controlled trial.
Subjects are randomized to two groups: experimental group takes preparation of botanical extract and control group takes placebo during four weeks.
Oral malodor is assessed by organoleptic teste and measurement of volatile sulfur compounds. Furthermore, salivary periodontal pathogens related with oral malodor are examined.
Efficacy
organoleptic score, measurement of volatile sulfur compounds in breath, periodontal pathogens in saliva
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
No need to know
2
Prevention
Food |
Preparation of botanical extract group: During the 4 weeks, subjects eat two tablets of preparations five times per day (after three main meals, between one of the main meals and before bedtime).
Placebo group: During the 4 weeks, subjects eat two tablets of control preparations five times per day (after three main meals, between one of the main meals and before bedtime).
20 | years-old | < |
70 | years-old | > |
Male and Female
Subjects with physiological halitosis
# Organoreptic score >=2 and total volatile sulfur compounds >=0.15 ppm
# All periodontal probing depth of six teeth selected from the six areas <4mm
# Mean gingival index <2 and mean plaque index <2
Subjects without physiological halitosis
A history of systemic disease
Antibiotic treatment or periodontal treatment within the previous 3 months
40
1st name | |
Middle name | |
Last name | Muneo Tanaka |
Osaka University Dental Hospital
Department of Preventive Dentistry
1-8, Yamadaoka, Suita, Osaka, Japan
06-6879-2922
1st name | |
Middle name | |
Last name | Muneo Tanaka |
Osaka University Dental Hospital
Department of Preventive Dentistry
1-8, Yamadaoka, Suita, Osaka, Japan
06-6879-2922
Osaka University Dental Hospital Department of Preventive Dentistry
Foodstuffs company
Profit organization
Japan
None
None
NO
2009 | Year | 08 | Month | 01 | Day |
Unpublished
Completed
2009 | Year | 07 | Month | 01 | Day |
2009 | Year | 08 | Month | 01 | Day |
2010 | Year | 03 | Month | 01 | Day |
2009 | Year | 06 | Month | 30 | Day |
2010 | Year | 02 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002623
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