Unique ID issued by UMIN | UMIN000002221 |
---|---|
Receipt number | R000002728 |
Scientific Title | The screening method of reduced-function CYP2C19 polymorphisms in Japanese male |
Date of disclosure of the study information | 2009/08/01 |
Last modified on | 2012/10/01 13:51:36 |
The screening method of reduced-function CYP2C19 polymorphisms in Japanese male
The screening method of CYP2C19 polymorphisms
The screening method of reduced-function CYP2C19 polymorphisms in Japanese male
The screening method of CYP2C19 polymorphisms
Japan |
clopidgrel resistance
Cardiology |
Others
YES
The aim of study is the establishment of easy screening method of clopidgrel resistance. The 13CO2 breath test after taking 13C-Pantoprazole can identify the reduced function CYP2C19 polymorphisms.
Pharmacodynamics
Confirmatory
Explanatory
Not applicable
Comparison the inhibition of platelet aggregation of clopidgrel between CYP2C19 wild type and reduced function polymorphisms judged by 13CO2 breath test.
Comparison the activity of CYP2C19 judged by 13CO2 breath test between the CYP2C19 wild type and r polymorphisms determined by gene analysis.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Device,equipment |
Breath test after taking 13C-pantoprazole 100mg
20 | years-old | <= |
Not applicable |
Male
Healthy male who was identified CYP2C19 gene and thr response to Clopidgrel
The history of allergy to proton pump inhibitor
Liver dysfunction (AST>100IU/L ALT>100IU/L)
Granulocytopenia
30
1st name | |
Middle name | |
Last name | Hisanori Horiuchi |
Kyoto university hospital
The department of cardiovascular medicine
54 Kawaramachi Syogoin Sakyo- kukyoto-city, Japan 606-0916
075-751-4255
1st name | |
Middle name | |
Last name | Junichi Tazaki |
Kyoto university hospital
The department of cardiovascular medicine
54 Kawaramachi Syogoin Sakyo- kukyoto-city, Japan 606-0916
075-751-4255
jun1@kuhp.kyoto-u.ac.jp
Department of Cardiovascular Medicine, Kyoto University Hospital
None
Self funding
NOne
NO
京都大学医学部附属病院
2009 | Year | 08 | Month | 01 | Day |
Published
Completed
2009 | Year | 07 | Month | 13 | Day |
2009 | Year | 08 | Month | 01 | Day |
2010 | Year | 01 | Month | 01 | Day |
2009 | Year | 07 | Month | 18 | Day |
2012 | Year | 10 | Month | 01 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002728
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |