Unique ID issued by UMIN | UMIN000002435 |
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Receipt number | R000002980 |
Scientific Title | Assessment of a combination therapy with Candesartan and Celecoxib for patients with advanced hepatocellular carcinoma after transhepatic arterial chemoembolization. |
Date of disclosure of the study information | 2009/09/02 |
Last modified on | 2012/03/05 09:38:03 |
Assessment of a combination therapy with Candesartan and Celecoxib for patients with advanced hepatocellular carcinoma after transhepatic arterial chemoembolization.
Phase 2 randomized trial of a combination therapy with Candesartan and Celecoxib for advanced HCC patients
Assessment of a combination therapy with Candesartan and Celecoxib for patients with advanced hepatocellular carcinoma after transhepatic arterial chemoembolization.
Phase 2 randomized trial of a combination therapy with Candesartan and Celecoxib for advanced HCC patients
Japan |
unresectable advanced hepatocellular carcinoma
Hepato-biliary-pancreatic medicine |
Malignancy
NO
The aim of this study is to assess the efficacy of a combination therapy with Celecoxib and Candesartan for unresectable advanced HCC patients.
Safety,Efficacy
Confirmatory
Pragmatic
Phase II
Time to progression
Survival period
Interventional
Parallel
Randomized
Individual
Open -but assessor(s) are blinded
Placebo
YES
YES
Institution is not considered as adjustment factor.
NO
Numbered container method
2
Treatment
Medicine |
Celecoxib and Candesartan
plasebo
20 | years-old | <= |
Not applicable |
Male and Female
1) HCC patients treated with TACE
2) Serum creatinine; less than 1.5 mg/dl, WBC; more than 2000, Total bilirubine; less than 3.0 mg/dl.
3) Performance status; ECOG 0-2
4) Liver damage; Child-Pugh class A or B
5) Patients without any influences of previous treatment.
1) pregnant woman, patients with severe thrombosis in past 6 months, patients with past history of peptic ulcer.
2) patients less than 120 mmHg of systolic blood pressure
80
1st name | |
Middle name | |
Last name | Michio Sata |
Kurume University, School of Medicine
Department of Medicine, Division of Gastroenterology
67 Asahi-machi, Kurume City, Japan
0942-31-7561
1st name | |
Middle name | |
Last name | Takuji Torimura |
Kurume University, School of Medicine
Department of Medicine, Division of Gastroenterology
67 Asahi-machi, Kurume City, Japan
0942-31-7561
tori@med.kurume-u.ac.jp
Kurume University, School of Medicine,Department of Medicine, Division of Gastroenterology
Kurume University, School of Medicine,Department of Medicine, Division of Gastroenterology
Self funding
NO
久留米大学医学部内科学講座消化器内科部門
2009 | Year | 09 | Month | 02 | Day |
Unpublished
Open public recruiting
2008 | Year | 09 | Month | 01 | Day |
2008 | Year | 09 | Month | 01 | Day |
2011 | Year | 10 | Month | 01 | Day |
2009 | Year | 09 | Month | 02 | Day |
2012 | Year | 03 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000002980
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