Unique ID issued by UMIN | UMIN000002639 |
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Receipt number | R000003217 |
Scientific Title | Occurance of residual neuromuscular blockade in patients received general anesthesia |
Date of disclosure of the study information | 2009/10/18 |
Last modified on | 2009/11/09 16:23:51 |
Occurance of residual neuromuscular blockade in patients received general anesthesia
General aneshtesia and residual neuromuscular blockade
Occurance of residual neuromuscular blockade in patients received general anesthesia
General aneshtesia and residual neuromuscular blockade
Japan |
Diseases which need operation under general anesthesia
Anesthesiology |
Others
NO
It is pointed out when the recovery of neuromuscular function is not enough after surgery, serious respiratory disorders such as oxygen desaturation will emerge at a high rate. So, we investigate the incidence of residual neuromuscular blockade after surgery by multicenter study.
Safety
The number of patients whose TOF ratio <0.9 after tracheal extubation
1. Total rocuronium dose
2. Time from extubation to measurement of TOF ratio
3. Time from latest rocuronium use to extubation
4. Time from administration of reversal agent to extubation
5. The difference of TOF ratio between existence or nonexistence of reversal agent
6. The difference of TOF ratio among the anesthetic managements
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
1. Induction and maintenance of anesthesia is done with anesthetics and analgesics which are appropriate for the surgical patients' conditions. Either inhalational anesthesia or TIVA is used.
2. Tracheal intubation is done after adequate dose of rocronium is injected.
3. Intraoperative rocuronium useage is determined by the anesthesiologist.
4. After surgery, recovery of neuromuscular blockade is done by spontaneous recovery or by reversal agent (neostigmine and atropine).
5. After comfirmation of recovery from neuromuscular blockade, tracheal extubation is done.
6. After extubation and the patients are stable, TOF ratio at the thumb is measured by neuromuscular monitor(TOF-Watch) giving TOF stimulation(50mA) to ulnar nerve at fifteen seconds interval. When the difference of two data is over 10%, the measuring repeats until four mesuring is done. The measuring is done with hand adaptor.
7. When the TOF ratio<0.9, the reversal is considered once agein and the respiratory condition is checkd. When the reversal agent is administered once again, another TOF ratio is measured.
20 | years-old | <= |
Not applicable |
Male and Female
Patients, aged 20 or over (ASA phisical status 1-3) and who is operated under general anesthesia using rocuronium.
Patients who have a history of hypersensitivity to rocuronium and bromide.
Patients who have myasthenia gravis and myasthenic syndrome.
25
1st name | |
Middle name | |
Last name | Itsuo Nakatsuka |
Keio University Hospital
Anesthesiology
35 Shinanomachi, Shinjuku-ku, Tokyo, Japan
1st name | |
Middle name | |
Last name |
Keio University Hospital
Anesthesiology
35 Shinanomachi, Shinjuku-ku, Tokyo, Japan
4 University investigation of neuromuscular blockade
none
Other
NO
2009 | Year | 10 | Month | 18 | Day |
Unpublished
Completed
2009 | Year | 10 | Month | 08 | Day |
2009 | Year | 10 | Month | 01 | Day |
2009 | Year | 11 | Month | 01 | Day |
2009 | Year | 10 | Month | 18 | Day |
2009 | Year | 11 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000003217
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