Unique ID issued by UMIN | UMIN000003417 |
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Receipt number | R000004139 |
Scientific Title | Efficacy and safety of switching from angiotensin II receptor blocker-diuretic combinations therapy to combination tablets (candesartan cilexetil-hydrochlorothiazide) in hypertension. |
Date of disclosure of the study information | 2010/04/01 |
Last modified on | 2014/03/31 16:50:43 |
Efficacy and safety of switching from angiotensin II receptor blocker-diuretic combinations therapy to combination tablets (candesartan cilexetil-hydrochlorothiazide) in hypertension.
BLOARD study
Efficacy and safety of switching from angiotensin II receptor blocker-diuretic combinations therapy to combination tablets (candesartan cilexetil-hydrochlorothiazide) in hypertension.
BLOARD study
Japan |
Hypertensive patients receiving combined therapy with candesartan cilexetil and diuretic
Cardiology |
Others
NO
To evaluate the efficacy and safety of ECARD HD (candesartan cilexetil-hydrochlorothiazide) switched from combined therapy with candesartan cilexetil and diuretic
Safety,Efficacy
Confirmatory
Pragmatic
Not applicable
1.Change in blood pressure (absolute value)
2.Changes in uric acid (absolute value)
1.TC, TG, HDL-C
2.BNP
3.cystatin C
4.blood glucose level (HbA1c, fasting blood sugar)
5.urinary albumin, urinary sodium
6.safety : serum potassium
Interventional
Single arm
Non-randomized
Open -no one is blinded
Active
1
Treatment
Medicine |
combination tablets (ARB/diuretics)
ARB/diuretics combinations
20 | years-old | <= |
90 | years-old | >= |
Male and Female
1.Patient who was diagnosed as hypertension
2.Patient who recieves continuous candesartan and diuretic treatment
3.ambulatory patient
4.Patient who understands the contents of the informed consent form.
5.Patient who agrees with contraception during the study period
1.Patient who is anuric and/or dialysis
2.Patient with ARF (acute renal failure)
3.Patient with sodium - and potassium - depletion / sodium - and potassium - depleted patients
4.Patient who is pregnant or possibly pregnant
5.Patients with a history of hypersensitivity to ingredients of Ecard HD (candesartan cilexetil-hydrochlorothiazide) or other thiazide or thiazide-like diuretics
6.Patient who is determined to be excluded from the study due to any reason by the study doctor
70
1st name | |
Middle name | |
Last name | Kouji Kajinami |
Kanazawa Medical University Hospital
Department of Cardiology
1-1 Daigaku,Uchinada,Kahoku,Ishikawa
076-286-2211
kajinami@kanazawa-med.ac.jp
1st name | |
Middle name | |
Last name | Kouji Kajinami |
Kanazawa Medical University Hospital
Department of Cardiology
1-1 Daigaku,Uchinada,Kahoku,Ishikawa
076-286-2211
kajinami@kanazawa-med.ac.jp
Kanazawa Medical University Hospital
Kanazawa Medical University Hospital
Self funding
NO
金沢医科大学病院(石川県)
2010 | Year | 04 | Month | 01 | Day |
Unpublished
Completed
2010 | Year | 01 | Month | 22 | Day |
2010 | Year | 04 | Month | 01 | Day |
2011 | Year | 12 | Month | 01 | Day |
2012 | Year | 03 | Month | 01 | Day |
2012 | Year | 03 | Month | 01 | Day |
2013 | Year | 03 | Month | 31 | Day |
2010 | Year | 03 | Month | 31 | Day |
2014 | Year | 03 | Month | 31 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000004139
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