Unique ID issued by UMIN | UMIN000003425 |
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Receipt number | R000004147 |
Scientific Title | Effects of low-carbohydrate diet on preferential abdominal fat loss for 6 months in type 2 diabetes |
Date of disclosure of the study information | 2010/04/01 |
Last modified on | 2015/02/25 20:16:18 |
Effects of low-carbohydrate diet on preferential abdominal fat loss for 6 months in type 2 diabetes
Effects of low-carbohydrate diet on abdominal fat distribution in type 2 diabetes
Effects of low-carbohydrate diet on preferential abdominal fat loss for 6 months in type 2 diabetes
Effects of low-carbohydrate diet on abdominal fat distribution in type 2 diabetes
Japan |
Type 2 diabetes
Endocrinology and Metabolism |
Others
NO
To clarify which abdominal fat tissues(visceral fat, subcutaneuse fat) would be preferentially reduced by a 6-month low-carbohydrate diet in patients with type 2 diabetes.
Others
To investigate changes in visceral fat and subcutaneouse fat by low- carbohydrate diet on 3 and 6 months in patients with type 2 diabetes.
Confirmatory
Explanatory
Not applicable
Body mass index, visceral fat and subcutaneouse fat measured by CT, insulin, fasting blood glucose, HbA1c, total energy intake,%carbohydrate, %protein and %fat assessed by dietary food records(at baseline,after 3-month, after6- month).
blood pressure, serum lipid profiles, albumin-creatinine ratio of spot urine(at baseline,after 3-month, after6- month).
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Food |
a low-carbohydrate diet
20 | years-old | <= |
85 | years-old | >= |
Male and Female
Patients with type 2 diabetes and HbA1c levels of 6.5% or above.
Patients with serum creatinine levels > 1.5 mg/dl, severe diabetes complications (proliferative retinopathy, symptomatic neuropathy or diabetic foot), ketoacidosis, soft drink ketosis, cancer, severe heart failure and liver cirrhosis.
50
1st name | |
Middle name | |
Last name | Hajime Haimoto |
Haimoto Clinic
Division of Internal Medicine
1-80 Yayoi-cho, Kasugai, 486-0838 Aichi, Japan
0568-85-0567
1st name | |
Middle name | |
Last name | Hajime Haimoto |
Haimoto Clinic
Division of Internal Medicine
1-80 Yayoi-cho, Kasugai, 486-0838 Aichi, Japan
0568-85-0567
Himoto Clinic
Himoto Clinic
Self funding
NO
医療法人芍薬会灰本クリニック(愛知県)
2010 | Year | 04 | Month | 01 | Day |
http://www.dovepress.com/effects-of-a-moderate-low-carbohydrate-diet-on-preferential-abdominal--peer-reviewed-article-DMSO
Published
http://www.dovepress.com/effects-of-a-moderate-low-carbohydrate-diet-on-preferential-abdominal--peer-reviewed-article-DMSO
The patients showed good compliance with the LCD (1812 +/- 375 kcal/day, % carbo-hydrate:fat:protein = 35:40:19 for men; 1706 +/- 323 kcal/day, % carbohydrate:fat:protein = 41:36:21 for women). Significant decreases (P = 0.05) in BMI and HbA1c levels were observed, along with an increase in HDL-C (P = 0.021) in men and a decrease in LDL-C (P = 0.001) in women. VAT (21.6 cm2, P < 0.001 in men;19.6 cm2;, P < 0.001 in women) and SAT (13.5 cm2, P = 0.004 in men;19.1 cm2, P = 0.003 in women) significantly decreased. The loss of VAT (%deltaVAT) was greater than that of SAT (%deltaSAT) in women (P = 0.022). A similar but not significant predominance of VAT loss was detected in men (P = 0.111). In women, the %deltaSAT significantly correlated with changes in FBG (deltaFBG) (r = 0.417) and HDL-C (deltaHDL) (r = 0.720), as was %deltaVAT with changes in triglyceride (deltaTG) (r = 0.591).
Completed
2009 | Year | 10 | Month | 01 | Day |
2009 | Year | 11 | Month | 01 | Day |
2010 | Year | 11 | Month | 30 | Day |
2010 | Year | 12 | Month | 31 | Day |
2010 | Year | 12 | Month | 31 | Day |
2011 | Year | 01 | Month | 31 | Day |
2010 | Year | 04 | Month | 01 | Day |
2015 | Year | 02 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000004147
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