Unique ID issued by UMIN | UMIN000003473 |
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Receipt number | R000004203 |
Scientific Title | the study on the relationship between renin activity and hypotensive efficacy of uncombined angiotensin II receptor blockers(ARB) therapy and combined ARB+diuretic therapy for hypertension |
Date of disclosure of the study information | 2010/04/09 |
Last modified on | 2014/10/09 09:46:14 |
the study on the relationship between renin activity and hypotensive efficacy of uncombined angiotensin II receptor blockers(ARB) therapy and combined ARB+diuretic therapy for hypertension
study of relationship between drug therapy with ARB and diuretic and renin activity
the study on the relationship between renin activity and hypotensive efficacy of uncombined angiotensin II receptor blockers(ARB) therapy and combined ARB+diuretic therapy for hypertension
study of relationship between drug therapy with ARB and diuretic and renin activity
Japan |
hypertension
Cardiology |
Others
NO
to examine whether or not the use of a diuretic agent in combination with ARB can induce further elevation of renin activity compared to ARB only, and the relationship between renin activity and hypotensive effect
Pharmacodynamics
hypotensive effect
renin activity
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
telmisartan 40mg, 7days
>telmisartan 40mg+hydrochlorothiazide 12.5mg, 7days
20 | years-old | <= |
80 | years-old | > |
Male and Female
1. individuals with systolic blood pressure >=130mmHg and <180mmHg and/or diastolic blood pressure >=85mmHg and <110mmHg.
2. individuals who have not been received hypotensors except for Ca antagonists.
3. BMI: >=18kg/m2, <30kg/m2
4. individuals capable of understanding the study protocol and complying with the related instructions.
1. secondary hypertension
2. individuals with serious complications
3. pregnant and lactating women
20
1st name | |
Middle name | |
Last name | Kyoichi Ohashi |
Oita University Faculty of Medicine
Dept of clinical pharmacology and therapeutics
1-1 Idaigaoka Hasama Yufu-city, Oita, JAPAN
097-586-5952
rinyaku@oita-u.ac.jp
1st name | |
Middle name | |
Last name | Hiromitsu Imai |
Oita university Faculty of medicine
Dept of clinical pharmacology and therapeutics
1-1 Idaigaoka Hasama Yufu-city, OIta, JAPAN
097-586-5952
imaih@oita-u.ac.jp
J-CLIPNET
research grant from government
NO
2010 | Year | 04 | Month | 09 | Day |
Unpublished
Terminated
2009 | Year | 12 | Month | 24 | Day |
2010 | Year | 06 | Month | 01 | Day |
2010 | Year | 04 | Month | 09 | Day |
2014 | Year | 10 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000004203
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