Unique ID issued by UMIN | UMIN000003571 |
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Receipt number | R000004329 |
Scientific Title | Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction |
Date of disclosure of the study information | 2010/05/10 |
Last modified on | 2017/05/11 09:27:42 |
Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction
Stat-LVDF Study
Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction
Stat-LVDF Study
Japan |
Patients with left ventricular diastolic dysfunction as well as hypercholesterolemia
Cardiology |
Others
NO
To compare the effect of hydrophilic and hydrophobic statins on the left ventricular diastolic dysfunction in patients with hypercholesterolemia
Efficacy
Diastolic dysfunction by Doppler echocardiography
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Hydrophilic statin
dose: according to Japan Atherosclerosis Sociaty Guideline
duration: 24 weeks
Hydrophobic statin
dose: according to Japan Atherosclerosis Sociaty Guideline
duration: 24 weeks
30 | years-old | <= |
80 | years-old | > |
Male and Female
1. Echocardiography: EF>45%, E/A<1, Dct>=210msec
2. Total cholesterol<280mg/dL or LDL-C<200mg/dL
3. LDL-C levels are to be treated according to the guideline by Japan Atherosclerosis Society
1. Statin treatment within 3 months
2. Possible change in treatment for hypertemnsion or chronic heart failure
3. Myocardial infarction in 1 month
4. Coronary angioplasty or bypass surgery within 1 month or possible coronary angioplasty or bypass surgery within 3 months
5. Active malignancy
6. Severe liver dysfunction
7. Serum creatinin > 2.0mg/dL
8. Steriod or immunosupressant use
9. Pregnancy or lactation
84
1st name | |
Middle name | |
Last name | koji Hasegawa |
National Hospital Organization Kyoto Medical Center
Division of Translational Research
1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto
075-641-9161
koj@kuhp.kyoto-u.ac.jp
1st name | |
Middle name | |
Last name | koji Hasegawa |
National Hospital Organization Kyoto Medical Center
Division of Translational Research
1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, Japan
075-641-9161
koj@kuhp.kyoto-u.ac.jp
National Hospital Organization Kyoto Medical Center
Kowa Pharmaceutical
Profit organization
NO
2010 | Year | 05 | Month | 10 | Day |
Published
Completed
2010 | Year | 04 | Month | 30 | Day |
2010 | Year | 05 | Month | 01 | Day |
2010 | Year | 05 | Month | 06 | Day |
2017 | Year | 05 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000004329
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