Unique ID issued by UMIN | UMIN000003899 |
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Receipt number | R000004690 |
Scientific Title | Analysis of HE4(WFDC2) expression as a new candidate molecular marker of gastric cancer. |
Date of disclosure of the study information | 2010/07/09 |
Last modified on | 2012/09/17 09:49:05 |
Analysis of HE4(WFDC2) expression as a new candidate molecular marker of gastric cancer.
Analysis of gene expressions of new candidates for gastric cancer molecular markers.
Analysis of HE4(WFDC2) expression as a new candidate molecular marker of gastric cancer.
Analysis of gene expressions of new candidates for gastric cancer molecular markers.
Japan |
Gastric Cancer
Gastroenterology | Gastrointestinal surgery |
Malignancy
NO
Gastric cancer remains the second leading cause of cancer-related death worldwide.
We recently reported that HE4(WFDC2) was expressed in both gastric metaplasia and intestinal metaplasia, furthermore, HE4 expressed in the vast majority of intestinal type and signet ring gastric adenocarcinomas.
*Nozaki K et al. Gastroenterology 134(2):511-522, 2008.
In this study, we evaluate up-regulation of this novel secreted mediator, HE4(WFDC2), as surrogate marker of the preneoplastic process.
Bio-availability
Confirmatory
Pragmatic
Phase II
HE4(WFDC2) mRNA expression level and protein transcripts, OS(Overall Survival), progression and pathological / biological characteristics of the gastric cancers.
HE4(WFDC2) mRNA expression level and protein transcripts, before surgical resection of gastric cancer, after surgical resection, during adjuvant chemotherapy, and after chemotherapy.
Observational
Not applicable |
Not applicable |
Male and Female
Gastric cancer patients, who have been notified about the diagnosis, and have planned for admission for surgical resection of gastric cancer.
Not applied
300
1st name | |
Middle name | |
Last name | Koji Nozaki MD, PhD |
The University of Tokyo Hospital
Gastrointestinal Surgery
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JAPAN
03-3815-5411
1st name | |
Middle name | |
Last name | Koji Nozaki MD, PhD |
The University of Tokyo Hospital
Clinical Research Support Center
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JAPAN
03-3815-5411
knozaki-tky@umin.ac.jp
The University of Tokyo
Grants-in-Aid for Scientific Research
NO
2010 | Year | 07 | Month | 09 | Day |
Unpublished
Completed
2009 | Year | 07 | Month | 27 | Day |
2010 | Year | 07 | Month | 01 | Day |
2010 | Year | 07 | Month | 09 | Day |
2012 | Year | 09 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000004690
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