Unique ID issued by UMIN | UMIN000004717 |
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Receipt number | R000005614 |
Scientific Title | Effects of a low-carbohydrate diet on carotid artery intima-media thickness,urinary albumin excretion and eGFR in patients with type 2 diabetes: a 2-year intervention study |
Date of disclosure of the study information | 2011/01/01 |
Last modified on | 2015/02/25 20:24:27 |
Effects of a low-carbohydrate diet on carotid artery intima-media thickness,urinary albumin excretion and eGFR in patients with type 2 diabetes: a 2-year intervention study
Effects of a low-carbohydrate diet on atherosclerosis in type 2 diabetes
Effects of a low-carbohydrate diet on carotid artery intima-media thickness,urinary albumin excretion and eGFR in patients with type 2 diabetes: a 2-year intervention study
Effects of a low-carbohydrate diet on atherosclerosis in type 2 diabetes
Japan |
Type 2 diabetes
Cardiology | Endocrinology and Metabolism | Nephrology |
Others
NO
To comfirm effects of a low-carbohydrate diet for two years on carotid artery intima-media thickness,urinary albumin excretion and eGFR among patients with type 2 diabetes.
Efficacy
Carotid artery intima-media thickness measured by echography, urinary albumin excretion, eGFR, BMI, fasting plasma glucose, serum insulin, HbA1c and serum lipid profiles
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Behavior,custom |
A carbohydratelow-carbohydrate diet (diatary %energy from carbohydrates ranging from 30% to 40%)
30 | years-old | <= |
80 | years-old | >= |
Male and Female
Patients with type 2 diabetes
Patients with serum creatinine levels greater than 1.5mg/dl, severe diabetes complications, ketoacidosis, soft drink ketosis, cancer, severe heart failure or liver cirrhosis
120
1st name | |
Middle name | |
Last name | Hajime Haimoto |
Haimoto Clinic
Department of internal medicine
1-80 Yayoi, Kasugai, Aichi
0568-85-0567
haimoto@gol.com
1st name | |
Middle name | |
Last name | Hajime Haimoto |
Haimoto Clinic
Department of internal medicine
1-80 Yayoi, Kasugai, Aichi
0568-85-0567
haimoto@gol.com
Haimoto Clinic
Haimoto Clinic
Self funding
Department of Preventive Medicine, Nagoya University Graduate School of Medicine
NO
2011 | Year | 01 | Month | 01 | Day |
Published
http://www.nutritionandmetabolism.com/content/11/1/33
At baseline, the mean HbA1c level and carbohydrate intake were 6.9 +/- 0.4% and 252 +/- 59 g/day for Group 1(n = 55), 8.1 +/- 0.4% and 282 +/- 85 g/day for Group 2 (n=41) and 10.6 +/- 1.4% and 309 +/- 88 g/day for Group 3 (n = 26). Following three-graded carbohydrate restriction for 6 months significantly decreased mean carbohydrate intake (g/day) and HbA1c levels for all patients, from 274 +/- 78 to168 +/- 52 g and from 8.1 +/- 1.6 to 7.1 +/- 0.9% (n = 122, P < 0.001 for both) and anti-diabetic drugs could be tapered. Delta-HbA1c and delta-carbohydrate were -0.4 +/- 0.4% and -74 +/- 69 g/day for Group 1, -0.6 +/- 0.9% and -117 +/- 78 g/day for Group 2 and -3.1 +/- 1.4% and -156 +/- 74 g/day for Group 3. The greater the reduction in carbohydrate intake (g/day), the greater the decrease in HbA1c levels (P < 0.001).
Main results already published
2010 | Year | 11 | Month | 15 | Day |
2010 | Year | 12 | Month | 01 | Day |
2013 | Year | 06 | Month | 30 | Day |
2013 | Year | 09 | Month | 30 | Day |
2013 | Year | 10 | Month | 31 | Day |
2013 | Year | 12 | Month | 31 | Day |
2010 | Year | 12 | Month | 13 | Day |
2015 | Year | 02 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005614
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