Unique ID issued by UMIN | UMIN000004761 |
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Receipt number | R000005668 |
Scientific Title | Effect of meal on pharmacokinetics of omeprazole and rabeprazole. |
Date of disclosure of the study information | 2011/12/21 |
Last modified on | 2013/06/21 15:40:08 |
Effect of meal on pharmacokinetics of omeprazole and rabeprazole.
PPI-PK
Effect of meal on pharmacokinetics of omeprazole and rabeprazole.
PPI-PK
Japan |
Gastroesophageal reflux disesae
Gastroenterology | Adult |
Others
YES
The purpose of the study is to examine pharmacokinetics of omeprazole and rabeprazole.
Pharmacokinetics
AUC of omeprazole and rabeprazole after meal
Interventional
Cross-over
Randomized
Open -but assessor(s) are blinded
Active
4
Treatment
Medicine |
omeprazole at fasting, washout 1-4 week, omeprazole after meal, washout 1-4 week, rabeprazole at fasting, washout 1-4 week, rabeprazole after meal
omeprazole after meal, washout 1-4 week, omeprazole at fasting, washout 1-4 week, rabeprazole after meal, washout 1-4 week, rabeprazole at fasting
rabeprazole at fasting, washout 1-4 week, rabeprazoleat after meal, washout 1-4 week, omeprazole at fasting, washout 1-4 week, omeprazoleafter meal
rabeprazole after meal, washout 1-4 week, rabeprazole at fasting, washout 1-4 week, omeprazole after meal, washout 1-4 week, omeprazole at fasting
20 | years-old | <= |
65 | years-old | >= |
Male
1. healthy volunteer
2. subjects with written informed consent
1. Subjects with past history of drug allergy including omeprazole and rabeprazole
2. Any liver, kidney, or heart diseases
3. Past history of GI tract surgery or vagotomy
4. Any medications due to any diseases
5. Subjects required medications during the study period
12
1st name | |
Middle name | |
Last name | Tomoyuki Koike |
Tohoku University Graduate School of Medicine
Division of Gastroenterology
1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan
022-717-7171
1st name | |
Middle name | |
Last name | Tomoyuki Koike |
Tohoku University Graduate School of Medicine
Division of Gastroenterology
1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan
022-717-7171
Tohoku University Graduate School of Midicine
Japanese Dyspepsia Association
Other
NO
東北大学病院(宮城県)
2011 | Year | 12 | Month | 21 | Day |
Unpublished
No longer recruiting
2010 | Year | 12 | Month | 17 | Day |
2010 | Year | 12 | Month | 01 | Day |
2010 | Year | 12 | Month | 20 | Day |
2013 | Year | 06 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005668
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