Unique ID issued by UMIN | UMIN000004795 |
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Receipt number | R000005708 |
Scientific Title | Treatment of Lambert-Eaton myasthenic syndrome with 3,4-diaminopyridin |
Date of disclosure of the study information | 2011/01/04 |
Last modified on | 2019/11/13 23:28:01 |
Treatment of Lambert-Eaton myasthenic syndrome with 3,4-diaminopyridin
Treatment of LEMS with diaminopyridin
Treatment of Lambert-Eaton myasthenic syndrome with 3,4-diaminopyridin
Treatment of LEMS with diaminopyridin
Japan |
Lambert-Eaton myasthenic syndrome
Medicine in general | Pneumology | Neurology |
Malignancy
NO
Lambert-Eaton myasthenic syndrome (LEMS) is a neuroimmunological condition, in which autoantibodies to calcium channels cause myasthenia and dysautonomia. It often accompanies lung cancer, particularly small cell carcinoma. 3,4-diaminopyridine (DAP) is known to enhance cholinergic transmission at the neuromuscular junction and used to treat LEMS in western countries. The present study aims to treatment LEMS with 3, 4 DAP.
Efficacy
Confirmatory
Pragmatic
Phase II
Neurological findings, Barthel Index, compound motor action potentials and waxing rate on nerve conduction studies conducted 1, 2, 4 months after treatment.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
3,4-diaminopyridine
Not applicable |
Not applicable |
Male and Female
1) Patients who are histopathologically diagnosed as lung cancer.
2) Patients who are electrically diagnosed to have Lambert-Eaton myasthenic syndrome.
3) Patients who are informed of their diagnosis.
4) Patients who do not have history of seizure or epilepsy.
5) Patients who agreed to participate in the present study by written informed consent.
Patients who are not able to comprehend the aim of the present study due to brain metastasis or metabolic encephalopathy are excluded.
5
1st name | |
Middle name | |
Last name | Yoshikazu Ugawa |
Fukushima Medical University
Department of Neurology
1 Hikarigaoka , Fukushima-shi, Fukushima-ken
024-547-1248
ugawa-tky@umin.net
1st name | |
Middle name | |
Last name | Shunsuke Kobayashi |
Fukushima Medical University
Department of Neurology
1 Hikarigaoka , Fukushima-shi, Fukushima-ken
024-547-1248
skoba66@fmu.ac.jp
Fukushima Medical University
MHLW
Japanese Governmental office
NO
福島県立医科大学付属病院
2011 | Year | 01 | Month | 04 | Day |
Unpublished
Terminated
2010 | Year | 12 | Month | 14 | Day |
2010 | Year | 12 | Month | 20 | Day |
2010 | Year | 01 | Month | 01 | Day |
2018 | Year | 01 | Month | 30 | Day |
2018 | Year | 11 | Month | 30 | Day |
2018 | Year | 11 | Month | 30 | Day |
2018 | Year | 12 | Month | 20 | Day |
2010 | Year | 12 | Month | 27 | Day |
2019 | Year | 11 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005708
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