Unique ID issued by UMIN | UMIN000005766 |
---|---|
Receipt number | R000006810 |
Scientific Title | Prophylactic use of low-dose PPI and recurrence of upper gastro-intetinal peptic ulcer in long-term Users of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or low-dose aspirin(LDA) |
Date of disclosure of the study information | 2011/06/15 |
Last modified on | 2016/06/15 14:54:00 |
Prophylactic use of low-dose PPI and recurrence of upper gastro-intetinal peptic ulcer in long-term Users of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or low-dose aspirin(LDA)
Prophylactic use of low-dose PPI and recurrence of upper gastro-intetinal peptic ulcer in long-term Users of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or low-dose aspirin(LDA)
Prophylactic use of low-dose PPI and recurrence of upper gastro-intetinal peptic ulcer in long-term Users of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or low-dose aspirin(LDA)
Prophylactic use of low-dose PPI and recurrence of upper gastro-intetinal peptic ulcer in long-term Users of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or low-dose aspirin(LDA)
Japan |
Peptic Ulcer
Medicine in general | Gastroenterology |
Others
NO
Purpose of this study is to examine influences by switching from standard-dose PPI regimen to half-dose lansoprazole(15 mg) regimen for peptic ulcer prevention.
Safety,Efficacy
Incidence rate of gastric or duodenal ulcer after treatment (gastrointestinal mucosal disorder with a lesion greater than or equal to 5 mm in diameter)
Changes in digestive symptom(GSRS) and gastro-intestinal mucosal injury (Mofified Lanza-Score), Incidence rate of Gastroesophageal reflux disease
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Medicine |
changing to lansoprazole 15 mg
20 | years-old | <= |
Not applicable |
Male and Female
1)Patients taking NSAIDs or LDA for more than a month
2)Patioents taking standard-dose PPI(omeprazole20mg,lansoprazole30mg, rabeprazole10mg)
3)Patients with past history of endoscopically documented gastric or duodenal ulcer
4)Patients with written informed consent
1) Patients with allergy for lansoprazole
2)Patients with allergy of atazanavir sulfate
3) Patients under treatment of peptic ulcer
4)Over Grade A reflux esophagitis according to Los Angeles classification (LA classification)
40
1st name | |
Middle name | |
Last name | Toshio Watanabe |
Osaka City University Graduate School of Medicine
Deaprtment of Gastroenterology
1-4-3 Asahimachi, Abenoku, Osaka 545-8585
06-6645-3811
ttanigawa@med.osaka-cu.ac.jp
1st name | |
Middle name | |
Last name | Tetsuya Tanigawa |
Osaka City University Graduate School of Medicine
Department of Gastroenterology
1-4-3 Asahimachi, Abenoku, Osaka 545-8585
06-6645-3811
ttanigawa@med.osaka-cu.ac.jp
Department of Gastroenterology, Osaka City University Graduate School of Medcine
Department of Gastroenterology, Osaka City University Graduate School of Medcine
Other
NO
2011 | Year | 06 | Month | 15 | Day |
Unpublished
Terminated
2011 | Year | 06 | Month | 15 | Day |
2011 | Year | 06 | Month | 01 | Day |
2011 | Year | 06 | Month | 13 | Day |
2016 | Year | 06 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000006810
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |