Unique ID issued by UMIN | UMIN000005785 |
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Receipt number | R000006823 |
Scientific Title | DNA mismatch repair (MMR) protein immunohistchemistry of hereditary non-polyposis colorectal cancer (HNPCC) related tumors and genetic analysis of MMR gene mutations. |
Date of disclosure of the study information | 2011/06/29 |
Last modified on | 2011/06/15 22:17:11 |
DNA mismatch repair (MMR) protein immunohistchemistry of hereditary non-polyposis colorectal cancer (HNPCC) related tumors and genetic analysis of MMR gene mutations.
DNA mismatch repair status of HNPCC related tumors
DNA mismatch repair (MMR) protein immunohistchemistry of hereditary non-polyposis colorectal cancer (HNPCC) related tumors and genetic analysis of MMR gene mutations.
DNA mismatch repair status of HNPCC related tumors
Japan |
HNPCC related tumor
Medicine in general | Gastroenterology | Hematology and clinical oncology |
Gastrointestinal surgery | Obstetrics and Gynecology | Dermatology |
Urology |
Malignancy
YES
This project is aiming to screen HNPCC or HNPCC suspicious patients by immunohistchemistry of tumors for loss of expression of MMR protein. Then, identified patients are surveyed according to a recommended guideline. Clinical features should be analyzed with the IHC results. We will add genetic or epigenetic analysis of MMR genes to MMR protein deficient tumors to identify the responsible alterations
Others
Diagnosis by immunohistchemical or genetic analyses
Screening of HNPCC related tumors by IHC for loss of MMR protein expression and observation of the clinical features assciated with MMR deficiency.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Gene |
IHC of MMR proteins, genetic or epigenetic analyses of MMR genes
16 | years-old | <= |
Not applicable |
Male and Female
Patients fulfilled Amsterdam criteria I, II or Bethesda guideline.
Patients suspected HNPCC or related syndrome such as Muir-Torre syndrome or Turcot syndrome.
Patients with written informed consent form.
Patients with no available sample.
Patients without written informed consent form.
50
1st name | |
Middle name | |
Last name | Chikashi Ishioka |
Institute of Development, Aging and Cancer, Tohoku University
Department of Clinical Oncology
4-1 Seiryo-machi, Aoba-ku, Sendai
1st name | |
Middle name | |
Last name | Hideki Shimodaira |
Institute of Development, Aging and Cancer, Tohoku University
Department of Clinical Oncology
4-1 Seiryo-machi, Aoba-ku, Sendai
Tohoku University
Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University
NO
2011 | Year | 06 | Month | 29 | Day |
Unpublished
Enrolling by invitation
2008 | Year | 10 | Month | 15 | Day |
2008 | Year | 11 | Month | 01 | Day |
2011 | Year | 06 | Month | 15 | Day |
2011 | Year | 06 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000006823
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