Unique ID issued by UMIN | UMIN000005966 |
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Receipt number | R000007054 |
Scientific Title | Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery |
Date of disclosure of the study information | 2011/07/12 |
Last modified on | 2016/02/28 23:17:38 |
Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery
Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery
Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery
Influence of angiotensin receptor blocker and direct renin inhibitor on renin-angiotensin-aldosterone system and left ventricular remodeling in patients with hypertension who underwent cardiac surgery
Japan |
Hypertension
Cardiology | Cardiovascular surgery |
Others
NO
To reserch the effects monotherapy of ARB or combination therapy of ARB and direct renin inhibitor ACE-I administration in influence for renin-angiotensin-aldosterone system and suppressing left ventricular remodeling.
Safety,Efficacy
1) RAAS
2) BNP
1) serum Cr
2) UCG (LVMI, EF)
3) Urinary albumin
4) cystatin C
5) Blood pressure, Heart rate
Interventional
Parallel
Randomized
Open -but assessor(s) are blinded
Active
2
Treatment
Medicine |
Olmesartan 40mg
Olmesartan 20mg+Aliskiren 150mg
20 | years-old | <= |
90 | years-old | >= |
Male and Female
Patients undergoing Cardiac surgery
Hypertensive patients (>125mmHg in systolic blood pressure) by Olmesatan (20mg/day).
Patients from whom informed consent was obtained
Patients who are pregnant or have possibility of pregnancy and are lactation period
Patients who have hyperkalemia
Patients who haverenal vascular hypertension
Patients who have secondary hypertension
Patients who were deemed not appropriate to participate in this study by doctor
100
1st name | |
Middle name | |
Last name | Akira Sezai |
Nihon University School of Medicine
Department of Cardiovascular Surgery
30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan
03-3972-8111
1st name | |
Middle name | |
Last name |
Nihon University School of Medicine
Department of Cardiovascular Surgery
Nihon University School of Medicine
None
Self funding
Sekino Hospital
NO
日大板橋病院(東京都)、関野病院(東京都)
2011 | Year | 07 | Month | 12 | Day |
Unpublished
Completed
2010 | Year | 11 | Month | 01 | Day |
2010 | Year | 12 | Month | 01 | Day |
2011 | Year | 07 | Month | 12 | Day |
2016 | Year | 02 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000007054
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