Unique ID issued by UMIN | UMIN000006763 |
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Receipt number | R000007442 |
Scientific Title | Topical and oral tranilast for treatment of dry eye associated with chronic graft-versus-host disease |
Date of disclosure of the study information | 2011/12/01 |
Last modified on | 2016/02/10 11:11:06 |
Topical and oral tranilast for treatment of dry eye associated with chronic graft-versus-host disease
Effect of tranilast for treatment of dry eye
Topical and oral tranilast for treatment of dry eye associated with chronic graft-versus-host disease
Effect of tranilast for treatment of dry eye
Japan |
Dry eye related to cGVHD
Ophthalmology |
Others
NO
To investigated the efficacy and safety of topical or oral tranilast for dry eye associated with cGVHD
Safety,Efficacy
Pragmatic
Phase I,II
visual analog scale
ocular surface vital staining
tear break up time
value of schirmer test
value of nasal stimulation test
visual acuity
functional visual acuity
tear stability analysis system
tear lipid interferometory
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
YES
2
Treatment
Medicine |
Topical tranilast
Oral tranilast
20 | years-old | <= |
75 | years-old | >= |
Male and Female
Diagnostic criteria
Tear Dynamics
Schirmer test ≤ 5 mm
Tear break up time ≤ 5 sec
Ocular surface condition
Rose Bengal staining ≥ 3 points
Fluorescein staining ≥ 3 points
Newly onset of dry eye patients after hematopoietic stem cell transplantation
Contact lens wearer
Infectious disease
Other ocular disease
44
1st name | |
Middle name | |
Last name | Yoko Ogawa |
Keio University School of Medicine
Department of Ophthalmology
35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan
03-3353-1211
1st name | |
Middle name | |
Last name | Yoko Ogawa |
Keio University School of Medicine
Department of Ophthalmology
35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan
03-5363-3972
Department of Ophthalmology, Keio University SchooL of medicine
None
Self funding
NO
2011 | Year | 12 | Month | 01 | Day |
Unpublished
Completed
2011 | Year | 08 | Month | 31 | Day |
2011 | Year | 09 | Month | 01 | Day |
2011 | Year | 11 | Month | 24 | Day |
2016 | Year | 02 | Month | 10 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000007442
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