Unique ID issued by UMIN | UMIN000006637 |
---|---|
Receipt number | R000007850 |
Scientific Title | The small intestine absorption test using the [1-13C] labeled substance, and a study of bacterial overgrowth in the intestine. |
Date of disclosure of the study information | 2011/10/31 |
Last modified on | 2013/11/08 23:57:16 |
The small intestine absorption test using the [1-13C] labeled substance, and a study of bacterial overgrowth in the intestine.
The small intestine absorption test using the [1-13C] labeled substance, and a study of bacterial overgrowth.
The small intestine absorption test using the [1-13C] labeled substance, and a study of bacterial overgrowth in the intestine.
The small intestine absorption test using the [1-13C] labeled substance, and a study of bacterial overgrowth.
Japan |
Liver cirrhosis, portal hypertension
Gastroenterology | Hepato-biliary-pancreatic medicine |
Others
NO
Dietary fatty acid could be a risk factor for hepatic inflammation and hepatocarcinogenesis. We evaluate the alteration for absorption of fatty acids in the patients with liver cirrhosis with or without portal hypertension, and want to identify its mechanism. Moreover, we want to evaluate the association with bacterial overgrowth in intestine.
Pharmacokinetics
Exploratory
Pragmatic
Not applicable
Time course of breath 13CO2 excretion after loading [1-13C]-labeled substances
The area under the curve of total breath 13CO2 excretion
Interventional
Parallel
Non-randomized
Open -no one is blinded
Uncontrolled
3
Diagnosis
Food |
We will enroll control subjects for this study from May, 2009 to April, 2014. After at least 12-h overnight fast, all subjects received substrates of [1-13C] labeled fatty acids or D-xylose using upper gastrointestinal tract endoscope in horizontal portion of duodenum. The breath samples were collected at before loading the substrates, and at every 15 min during first 30 min, then every 30 min during the following 5 hour 30 min (total was 360 min after loading).
For the breath samples, the ratio of 13CO2 divided by 12CO2 were analyzed by using non dispersive infrared spectrometry.
We will enroll patients with liver cirrhosis without portal hypertension for this study from May, 2009 to April, 2014. After at least 12-h overnight fast, all subjects received substrates of [1-13C] labeled fatty acids or D-xylose using upper gastrointestinal tract endoscope in horizontal portion of duodenum. The breath samples were collected at before loading the substrates, and at every 15 min during first 30 min, then every 30 min during the following 5 hour 30 min (total was 360 min after loading).
For the breath samples, the ratio of 13CO2 divided by 12CO2 were analyzed by using non dispersive infrared spectrometry.
We will enroll control subjects and patients with liver cirrhosis with portal hypertension for this study from May, 2009 to April, 2014. After at least 12-h overnight fast, all subjects received substrates of [1-13C] labeled fatty acids or D-xylose using upper gastrointestinal tract endoscope in horizontal portion of duodenum. The breath samples were collected at before loading the substrates, and at every 15 min during first 30 min, then every 30 min during the following 5 hour 30 min (total was 360 min after loading).
For the breath samples, the ratio of 13CO2 divided by 12CO2 were analyzed by using non dispersive infrared spectrometry.
20 | years-old | <= |
90 | years-old | > |
Male and Female
he people with or without liver cirrhosis who have a schedule to receive the endoscopic examination for stomach and intestine. All enrolled participants provided written informed consent to research testing under protocols approved by the Institutional Review Boards of Ehime University Hospital (approved number: 0904007).The study protocol conformed to the ethical guidelines of the Declaration of Helsinki.
We exclude the patients with diabetes or abnormality of lipid metabolism. We also exclude the patients who could not receive the examination by upper gastrointestinal tract endoscope due to systemic condition.
100
1st name | |
Middle name | |
Last name | Morikazu Onji |
Ehime University Graduate School of Medicine
Department of Gastroenterology and Metabology
Toon City, Ehime 791-0295, Japan
+81-89-960-5308
y79y81@gmail.com
1st name | |
Middle name | |
Last name | Yasunori Yamamoto |
Ehime University Graduate School of Medicine
Department of Gastroenterology and Metabology
Toon City, Ehime 791-0295, Japan
+81-89-960-5308
y79y81@yahoo.com
Ehime University Graduate School of Medicine
None
Self funding
NO
2011 | Year | 10 | Month | 31 | Day |
Unpublished
Enrolling by invitation
2009 | Year | 05 | Month | 01 | Day |
2009 | Year | 05 | Month | 01 | Day |
2015 | Year | 03 | Month | 01 | Day |
2015 | Year | 03 | Month | 01 | Day |
2015 | Year | 03 | Month | 01 | Day |
2015 | Year | 03 | Month | 01 | Day |
2011 | Year | 10 | Month | 31 | Day |
2013 | Year | 11 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000007850
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |