Unique ID issued by UMIN | UMIN000007499 |
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Receipt number | R000008847 |
Scientific Title | Safety and efficacy of preanesthetic H2 antagonist therapy for patients on oral rehydration therapy until 2 h before surgery |
Date of disclosure of the study information | 2012/03/14 |
Last modified on | 2012/09/19 11:12:56 |
Safety and efficacy of preanesthetic H2 antagonist therapy for patients on oral rehydration therapy until 2 h before surgery
Safety and efficacy of preanesthetic H2 antagonist therapy for patients on oral rehydration therapy until 2 h before surgery
Safety and efficacy of preanesthetic H2 antagonist therapy for patients on oral rehydration therapy until 2 h before surgery
Safety and efficacy of preanesthetic H2 antagonist therapy for patients on oral rehydration therapy until 2 h before surgery
Japan |
condition required surgery
Not applicable |
Malignancy
NO
The purpose is that we evaluate safety and efficacy of preanesthetic H2 antagonist therapy for patients on ORT until 2 h before surgery with measuring gastric fluid acidity, and volume of gastric contents.
Safety,Efficacy
gastric volume and its pH after anesthesia induction
Observational
20 | years-old | <= |
80 | years-old | >= |
Male and Female
Patients scheduled for elective surgery under general anesthesia
We excluted patients with gastrointestienal obstruction, body mass index (BMI) of 35 kg/m2 or larger, renal dysfunction (a creatinine clearance of 20ml/min or lower or dialysis ), pregnancy, the inability to take food orally, receiving gastroesophageal surgery previously, and long-term H2 antagonist medication.
80
1st name | |
Middle name | |
Last name | Masatou Kitayama |
Hirosaki University school of Medicine & Hospital
Department of Anesthesiology
Hontyo 53, Hirosaki, Aomori, 036-8562, Japan
1st name | |
Middle name | |
Last name | Masatou Kitayama |
Hirosaki University school of Medicine & Hospital
Department of Anesthesiology
Hontyo 53, Hirosaki, Aomori, 036-8562, Japan
Hirosaki University school of Medicine & Hospital
Hirosaki University school of Medicine & Hospital
Other
NO
2012 | Year | 03 | Month | 14 | Day |
Published
There were no significant differences between the groups with respect to sex, age, height, weight, and BMI. Neither gastric volume nor pH differed between the groups - ORT 9.6 (8.2) ml and 5.6 (1.7), respectively, vs. standard fasting 8.5 (6.8) ml and 5.5 (1.7), respectively. There was no incidence of vomiting or aspiration in either group during the induction of anesthesia. These data suggest that ORT may not reduce gastric volume in patients receiving a preanesthetic H2 antagonist.
Completed
2011 | Year | 11 | Month | 30 | Day |
2011 | Year | 11 | Month | 01 | Day |
Patients were randomly assigned to the ORS or the fasting group. Patients in both groups were premedicated orally with roxatidine 75mg at 21:00 the night before surgery and 2h before induction of anesthesia. Following a meal on the day before surgery, patients in the ORS group were given 1,000ml (into the operating room at 11:00) or 1,500ml (into the operating room at 13:00) of ORS (OS-1; Otsuka Pharmaceutical Factory, Tokushima, Japan) and allowed to consume the solution until 2h before surgery. Patients in the fasting group started fasting at 21:00 the night before surgery.
After tracheal intubation, a gastric tube was placed into the stomach, and its position was verified by auscultation of the epigastrium during insufflations of air. Gastric fluid was obtained by aspiration using a 30 ml syringe while changing the patient's position (supine, Trendelenburg,and reverse Trendelenburg, and right and left 20 degree semilateral positions) and with insufflation of 30 ml air plus upper-abdominal massage. The volume of gastric contents was recorded as well as the pH value, measured with a pH meter with 0.01 pH unit precision over the entire pH range (Ecoscan pH5 pH6; Iuchi Seieido Co, Ltd, Osaka, Japan) that was calibrated each morning.
2012 | Year | 03 | Month | 14 | Day |
2012 | Year | 09 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008847
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