Unique ID issued by UMIN | UMIN000007695 |
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Receipt number | R000009075 |
Scientific Title | Comparison of Effects of Pitavastatin and Rosuvastatin on Patients With Chronic Heart Failure |
Date of disclosure of the study information | 2012/04/10 |
Last modified on | 2012/04/09 09:47:00 |
Comparison of Effects of Pitavastatin and Rosuvastatin on Patients With Chronic Heart Failure
effects of pitavastatin on chronic heart failure
Comparison of Effects of Pitavastatin and Rosuvastatin on Patients With Chronic Heart Failure
effects of pitavastatin on chronic heart failure
Japan |
heart failure
Cardiology |
Others
NO
compare the effects of pitavastatin and rosuvastatin on low-density lipoprotein (LDL) - cholesterol level and various surrogate markers in hypercholesterolemic patients with CHF.
Safety,Efficacy
Confirmatory
serum LDL-cholesterol, total CoQ10 and the following biomarkers; markers of inflammation (high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha ) and pentraxin 3 (PTX3)), marker of the severity of heart failure (N-terminal pro-brain natriuretic peptide (NT-proBNP), tenascin C, and high-sensitivity cardiac troponin T (hs-TnT)), a marker of oxidative stress (urinary 8-isoprostane) and a marker of chronic kidney disease (urinary albumin to creatinine ratio (UACR)) at 12 weeks
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
treatment with pitavastatin
treatment withrosuvastatin
20 | years-old | <= |
79 | years-old | > |
Male and Female
New York Heart Association (NYHA) functional class II or III and a diagnosis as hypercholesterolemia
receiving treatment with a statin; taking a coenzyme Q10 (CoQ10) prior to the randomization and history of cardiac events. The ethics committee at Chiba University Graduate School of Medicine approved the OPAL protocol, which adhered according to the principles of the Helsinki Declaration
30
1st name | |
Middle name | |
Last name | Hiroshi Hasegawa |
Chiba University
Cardiovascular Science and Medicine
1-8-1 Inohana, Chuo-ku, Chiba
1st name | |
Middle name | |
Last name |
Chiba University
Cardiovascular Science and Medicine
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
Self funding
NO
2012 | Year | 04 | Month | 10 | Day |
Unpublished
Completed
2009 | Year | 05 | Month | 01 | Day |
2009 | Year | 07 | Month | 01 | Day |
2012 | Year | 04 | Month | 09 | Day |
2012 | Year | 04 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000009075
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