UMIN-CTR Clinical Trial
| Unique ID issued by UMIN | UMIN000008579 |
|---|---|
| Receipt number | R000009960 |
| Scientific Title | HER receptors regulated immunoescape from NK cell-mediated innnate immunity in non-small-cell lung cancer |
| Date of disclosure of the study information | 2012/09/01 |
| Last modified on | 2018/03/16 14:58:47 |
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Basic information
Public title
HER receptors regulated immunoescape from NK cell-mediated innnate immunity in non-small-cell lung cancer
Acronym
HER receptors regulated immunoescape in non-small-cell lung cancer
Scientific Title
HER receptors regulated immunoescape from NK cell-mediated innnate immunity in non-small-cell lung cancer
Scientific Title:Acronym
HER receptors regulated immunoescape in non-small-cell lung cancer
Region
| Japan |
Condition
Condition
operable cases of non-small-cell lung cancer
Classification by specialty
| Chest surgery |
Classification by malignancy
Malignancy
Genomic information
NO
Objectives
Narrative objectives1
HER signaling effects on NK cell-mediated cytotoxicity in non-small-cell lung cancer
Basic objectives2
Others
Basic objectives -Others
Immunological assessment
Trial characteristics_1
Confirmatory
Trial characteristics_2
Developmental phase
Not applicable
Assessment
Primary outcomes
Assess the effects of HER signaling on NK cell-mediated cytotoxicity in non-small-cell lung cancer
Key secondary outcomes
Base
Study type
Observational
Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment
Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10
Eligibility
Age-lower limit
| Not applicable |
Age-upper limit
| Not applicable |
Gender
Male and Female
Key inclusion criteria
Surgical cases of non-small-cell lung cancer in our institute
Key exclusion criteria
none
Target sample size
30
Research contact person
Name of lead principal investigator
| 1st name | |
| Middle name | |
| Last name | Riki Okita |
Organization
Kawasaki Medical School
Division name
General Thoracic Surgery
Zip code
Address
Matsushima 577, Kurashiki
TEL
0864621111
riki0716okita@yahoo.co.jp
Public contact
Name of contact person
| 1st name | |
| Middle name | |
| Last name | Riki Okita |
Organization
Kawasaki Medical School
Division name
General Thoracic Surgery
Zip code
Address
Matsushima 577, Kurashiki
TEL
086-464-1124
Homepage URL
gts@med.kawasaki-m.ac.jp
Sponsor or person
Institute
General Thoracic Surgery, Kawasaki Medical School
Institute
Department
Personal name
Funding Source
Organization
Kawasaki Medical School
Organization
Division
Category of Funding Organization
Self funding
Nationality of Funding Organization
Other related organizations
Co-sponsor
Name of secondary funder(s)
IRB Contact (For public release)
Organization
Address
Tel
Secondary IDs
Secondary IDs
NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW
Institutions
Institutions
川崎医科大学附属病院
Other administrative information
Date of disclosure of the study information
| 2012 | Year | 09 | Month | 01 | Day |
Related information
URL releasing protocol
Publication of results
Partially published
Result
URL related to results and publications
http://link.springer.com/article/10.1007%2Fs00262-016-1814-9
Number of participants that the trial has enrolled
Results
Okita R, et al. MHC class I chain-related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non-small cell lung cancer. Cancer Immunol Immunother 2016.
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description
Progress
Recruitment status
Completed
Date of protocol fixation
| 2012 | Year | 07 | Month | 09 | Day |
Date of IRB
Anticipated trial start date
| 2012 | Year | 07 | Month | 09 | Day |
Last follow-up date
| 2018 | Year | 03 | Month | 16 | Day |
Date of closure to data entry
| 2018 | Year | 03 | Month | 16 | Day |
Date trial data considered complete
| 2018 | Year | 03 | Month | 16 | Day |
Date analysis concluded
| 2018 | Year | 03 | Month | 22 | Day |
Other
Other related information
case control, prospective study
Management information
Registered date
| 2012 | Year | 07 | Month | 31 | Day |
Last modified on
| 2018 | Year | 03 | Month | 16 | Day |
Link to view the page
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000009960
| Research Plan | |
|---|---|
| Registered date | File name |
| Research case data specifications | |
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| Registered date | File name |
| Research case data | |
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| Registered date | File name |
