Unique ID issued by UMIN | UMIN000008711 |
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Receipt number | R000009989 |
Scientific Title | The influence of oral valproate on propofol metabolism |
Date of disclosure of the study information | 2012/08/18 |
Last modified on | 2020/02/04 11:10:14 |
The influence of oral valproate on propofol metabolism
The influence of oral valproate on propofol metabolism
The influence of oral valproate on propofol metabolism
The influence of oral valproate on propofol metabolism
Japan |
Patients with oral valproate
Neurology | Anesthesiology | Dental medicine |
Adult |
Others
NO
Evaluation of the influence of oral valproate on propofol metabolism by general anesthesia with propofol
Pharmacokinetics
Confirmatory
Pragmatic
Not applicable
The change of BIS index during anesthesia induction, the serum concentration of propofol after injection and the change of blood pressure and heart rate during anesthesia
Observational
16 | years-old | <= |
Not applicable |
Male and Female
Participants of the present study are patients who have the plan of a general anesthesia in Okayama university hospital.
Patients without consent of the study
48
1st name | Miyawaki |
Middle name | |
Last name | Takuya |
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Department of Dental Anesthsiology and Special Care Dentistry
700-8525
2-5-1 Shikata-cho, Kita-ku, Okayama, Japan
086-235-6721
miyawaki@md.okayama-u.ac.jp
1st name | Hitoshi |
Middle name | |
Last name | Higuchi |
Okayama University Hospital
Dental Anesthesiology
700-8525
2-5-1 Shikata-cho, Kita-ku, Okayama, Japan
086-235-6721
higuti@md.okayama-u.ac.jp
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Dental Anesthsiology and Special Care Dentistry
Okayama University
Other
The Ethics Committee of Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
086-235-6762
mae6605@adm.okayama-u.ac.jp
NO
2012 | Year | 08 | Month | 18 | Day |
Published
https://www.nature.com/articles/s41598-020-58460-2
33
There were no significant differences in the propofol level at 5, 10, 15, and 20 min or the free propofol level at 5 min after the intravenous administration of propofol. However, the minimum BIS was significantly lower and the time until the BIS exceeded 60 was significantly longer in the poly-VPA group. In the multivariate regression analysis, belonging to the poly-VPA group was found to be independently associated with the minimum BIS value and the time until the BIS exceeded 60.
2020 | Year | 02 | Month | 04 | Day |
Delay expected |
Data analysis and paper writing are in progress now.
Nothing
Completed
2012 | Year | 02 | Month | 28 | Day |
2012 | Year | 02 | Month | 28 | Day |
2012 | Year | 03 | Month | 01 | Day |
2018 | Year | 03 | Month | 31 | Day |
Prospective cohort study
We compare differences among three groups: the group of the patients with valproate acid, the one of patients with anti epileptic drugs with other than valproate acid and the one of patients without anti epileptic drugs.
2012 | Year | 08 | Month | 17 | Day |
2020 | Year | 02 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000009989
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