Unique ID issued by UMIN | UMIN000017335 |
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Receipt number | R000010078 |
Scientific Title | In vivo visualization of a-synuclein deposition by [11C]BF-227 PET in Parkinson's disease and Parkinsonian syndrome |
Date of disclosure of the study information | 2015/04/30 |
Last modified on | 2017/12/07 13:32:19 |
In vivo visualization of a-synuclein deposition by [11C]BF-227 PET in Parkinson's disease and Parkinsonian syndrome
In vivo visualization of a-synuclein deposition by [11C]BF-227 PET in Parkinson's disease and Parkinsonian syndrome
In vivo visualization of a-synuclein deposition by [11C]BF-227 PET in Parkinson's disease and Parkinsonian syndrome
In vivo visualization of a-synuclein deposition by [11C]BF-227 PET in Parkinson's disease and Parkinsonian syndrome
Japan |
Parkinson's disease and parkinsonian syndrome
Neurology |
Others
NO
The histopathological hallmark of Parkinson's disease and parkinsonian syndrome is the incidence of a-synuclein-containing Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs). However, in vivo visualization of a-synuclein depositions in the human brain remains to be impossible. We studied to demonstrate the potential of the binding of BF-227 to a-synuclein-containg LBs and GCIs.
Efficacy
Exploratory
Pragmatic
Not applicable
High uptake of BF-227 by PET image
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Diagnosis
Device,equipment |
Duration: from September, 2012 to August, 2022
Dose: about 333MBq of [11C]BF-227
20 | years-old | <= |
Not applicable |
Male and Female
Diagnostic criteria of Ministry of Health, Labour and Welfare
Patients with severe cardiac, renal, or liver diseases
Patients with pregnancy or breast-feeding
60
1st name | |
Middle name | |
Last name | Akio Kikuchi |
Tohoku University Graduate School of Medicine
Department of Neurology
1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
022-717-7189
akikuchi@med.tohoku.ac.jp
1st name | |
Middle name | |
Last name | Akio Kikuchi |
Tohoku University Graduate School of Medicine
Department of Neurology
1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
022-717-7189
akikuchi@med.tohoku.ac.jp
Tohoku University
Grant-in-Aid for Scientific Research (C)
Japanese Governmental office
Japan
NO
東北大学病院(宮城県)
2015 | Year | 04 | Month | 30 | Day |
Unpublished
Open public recruiting
2012 | Year | 07 | Month | 31 | Day |
2012 | Year | 09 | Month | 01 | Day |
2015 | Year | 04 | Month | 30 | Day |
2017 | Year | 12 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010078
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