Unique ID issued by UMIN | UMIN000008914 |
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Receipt number | R000010455 |
Scientific Title | Comparison of spironolactone and trichlormethiazide as add-on therapy to renin-angiotensin blockade for reduction of albuminuria in diabetic patients |
Date of disclosure of the study information | 2012/09/13 |
Last modified on | 2012/09/13 21:32:58 |
Comparison of spironolactone and trichlormethiazide as add-on therapy to renin-angiotensin blockade for reduction of albuminuria in diabetic patients
Spironolactone and thiazide in patients with diabetic nephropathy
Comparison of spironolactone and trichlormethiazide as add-on therapy to renin-angiotensin blockade for reduction of albuminuria in diabetic patients
Spironolactone and thiazide in patients with diabetic nephropathy
Japan |
Diabetic patients with persistent albuminuria
Endocrinology and Metabolism | Nephrology |
Others
NO
To compare the efficacy of spironolactone versus trichlormethiazide on changes in albuminuria, when either is used as add-on therapy to an ACE inhibitor or ARB in diabetic patients with CKD
Efficacy
Change in albuminuria at 24 weeks of treatment
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Oral administration of spironolactone (25 mg/day)
Oral administration of trichlormethiazide (2 mg/day)
40 | years-old | <= |
80 | years-old | > |
Male and Female
Japanese type 2 diabetic patients with urinary albumin-to-creatinine ratio (ACR) from first morning urine ≥ 100 mg/g and use of an ACE inhibitor or ARB for at least 6 months.
Patients with clinically significant heart, liver, infectious, or malignant disease, those with serum creatinine was ≥ 2.0 mg/dL, or those with serum potassium was ≥ 5.0 mEq/L or < 3.5 mEq/L.
40
1st name | |
Middle name | |
Last name | Tetsuya Babazono |
Tokyo Women's Medial University School of Medicine
Diabetes Center
8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan
03-3353-8111
1st name | |
Middle name | |
Last name | Tetsuya Babazono |
Tokyo Women's Medial University School of Medicine
Diabetes Center
8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan
03-3353-8111
Diabetes Center, Tokyo Women's Medial University School of Medicine
Diabetes Center, Tokyo Women's Medial University School of Medicine
Self funding
NO
東京女子医科大学糖尿病センター
2012 | Year | 09 | Month | 13 | Day |
Partially published
Completed
2001 | Year | 09 | Month | 30 | Day |
2001 | Year | 10 | Month | 12 | Day |
2012 | Year | 09 | Month | 13 | Day |
2012 | Year | 09 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010455
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