Unique ID issued by UMIN | UMIN000008951 |
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Receipt number | R000010497 |
Scientific Title | Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen. |
Date of disclosure of the study information | 2012/10/01 |
Last modified on | 2022/03/04 11:25:54 |
Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.
Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.
Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.
Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.
Japan |
allergic rhinitis
Oto-rhino-laryngology |
Others
NO
In the present study, an attempt is made to examine effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar. For this purpose, we use an environmental exposure unit and exposed the subjects to 8000 counts/m3 of Japanese cedar pollen for 3 hours in the off-season. Before exposure of pollen, ebastine was administrate at adose of 10mg, p.o. for 4 days and changes in expression of histamine H1 receptor and allergy-related cytokine mRNA in the nasal mucosa are measured.
Efficacy
Confirmatory
Explanatory
Not applicable
The expression of histamine H1 receptor and allergy-related cytokine mRNA in the nasal mucosa
The allergic rhinitis symptoms including sneezing, nasal discharge and nasal obstruction
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Ebastine is administrated p.o. at a dose of 10mg to the subjects for 4 days and then the artificial exposure of Japanese cedar pollen at the concentration of 8000 counts/m3.
20 | years-old | <= |
65 | years-old | >= |
Male and Female
Adult patients with allergic rhinitis to cedar pollen
1) Patients who have ever suffered from adverse event of ebastine.
2) Patients who was excluded by investigators.
40
1st name | Yoshiaki |
Middle name | |
Last name | Kitamura |
University of Tokushima School of Medicine
Department of Otolaryngology
770-8503
3-18-15 Kuramoto, Tokushima 770-8503, Japan
088-633-7169
ykitamura@tokushima-u.ac.jp
1st name | Yoshiaki |
Middle name | |
Last name | Kitamura |
University of Tokushima School of Medicine
Department of Otolaryngology
770-8503
3-18-15 Kuramoto, Tokushima 770-8503, Japan
088-633-7169
ykitamura@tokushima-u.ac.jp
University of Tokushima
University of Tokushima
Self funding
Committees for Medical Ethics of Tokushima University Hospital
2-50-1 Kuramoto, Tokushima 770-8503, Japan
088-633-9294
first-ec@clin.med.tokushima-u.ac.jp
NO
2012 | Year | 10 | Month | 01 | Day |
Unpublished
Enrolling by invitation
2012 | Year | 09 | Month | 15 | Day |
2012 | Year | 10 | Month | 01 | Day |
2012 | Year | 09 | Month | 20 | Day |
2022 | Year | 03 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010497
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