Unique ID issued by UMIN | UMIN000008971 |
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Receipt number | R000010523 |
Scientific Title | Safety and Efficacy analysis of 10 mg donepezil for severe Alzheimer's disease: switch from the other cholineseterase inhibitors |
Date of disclosure of the study information | 2012/10/01 |
Last modified on | 2015/09/28 19:52:36 |
Safety and Efficacy analysis of 10 mg donepezil for severe Alzheimer's disease: switch from the other cholineseterase inhibitors
Switch to 10 mg donepezil for severe Alzheimer's disease
Safety and Efficacy analysis of 10 mg donepezil for severe Alzheimer's disease: switch from the other cholineseterase inhibitors
Switch to 10 mg donepezil for severe Alzheimer's disease
Japan |
Alzheimer's disease
Neurology |
Others
NO
To examine efficacy and safety of switch from the other cholinesterase inhibitors to 10 mg donepezil
Safety,Efficacy
Confirmatory
Pragmatic
Not applicable
Mini Mental state examination
Neuropsychiatric Inventory
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Donepezil 10mg once a day
50 | years-old | <= |
90 | years-old | > |
Male and Female
1.Alzheimer's disease patients who meet the criteria of DSM-IV-TR
2.MMSE score of 1-20
3.Severe AD patients who took Galantamine and Rivastigmine
4.The spouse or another caregiver has to accompany the patient.
1.Patients with dementia except AD
2.Patients with high serum Vitamine level
3.Patients who are allergic to donepezil
50
1st name | |
Middle name | |
Last name | Yumiko Motoi |
Juntendo University School of Medicine
Department of Neurology
Hongo 2-1-1 Bunkyo Tokyo
0338133111
motoi@juntendo.ac.jp
1st name | |
Middle name | |
Last name | Yumiko Motoi |
Juntendo University School of Medicine
Department of Neurology
Hongo 2-1-1 Bunkyo Tokyo
0338133111
motoi@juntendo.ac.jp
epartment of Neurology, Juntendo University School of Medicine
None
Self funding
NO
2012 | Year | 10 | Month | 01 | Day |
Unpublished
Sufficient number of subjects did not complete this study because people with severe dementia stopped to visit the hospital.
Completed
2012 | Year | 09 | Month | 24 | Day |
2012 | Year | 10 | Month | 01 | Day |
2012 | Year | 09 | Month | 24 | Day |
2015 | Year | 09 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010523
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