Unique ID issued by UMIN | UMIN000009076 |
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Receipt number | R000010653 |
Scientific Title | Comparison of low dose-maintenance trial with dose-escalation trial in oral immunotherapy for food allergy |
Date of disclosure of the study information | 2012/10/10 |
Last modified on | 2022/04/18 09:42:08 |
Comparison of low dose-maintenance trial with dose-escalation trial in oral immunotherapy for food allergy
Comparison of low dose-maintenance trial with dose-escalation trial in oral immunotherapy for food allergy
Comparison of low dose-maintenance trial with dose-escalation trial in oral immunotherapy for food allergy
Comparison of low dose-maintenance trial with dose-escalation trial in oral immunotherapy for food allergy
Japan |
food allergy
Pediatrics | Child |
Others
NO
Comparison of safety and efficacy in low dose-maintenance trial with those in dose-escalation trial in oral immunotherapy for food allergy
Safety,Efficacy
Difference of threshold of tolerance dose after treatment between low dose-maintainance trial and dose-escalation trial in oral immunothearpy for food allergy
Interventional
Parallel
Non-randomized
Open -no one is blinded
Dose comparison
2
Treatment
Food |
gradually increased ingestion of responsible food
low dose ingestion of responsible food
1 | years-old | <= |
15 | years-old | >= |
Male and Female
Patients with immediate allergic reaction for food challenge test
Patients with poorly controlled asthma or atopic dermatitis
20
1st name | Masayuki |
Middle name | |
Last name | Akashi |
Saitama municipal hospital
Pediatrics
3368522
2460 mimuro midoriku saitama city
+81-48-873-4111
yuki0820@trust.ocn.ne.jp
1st name | Masayuki |
Middle name | |
Last name | Akashi |
Saitama municipal hospital
Pediatrics
3368522
2460 mimuro midoriku saitama city
0488734111
yuki0820@trust.ocn.ne.jp
Saitama municipal hospital
Kawano Masanori Memorial Foundation for Promotion of Pediatics
Non profit foundation
Saitama city hospital
2460 Mimuro Midori-ku Saitama
+81488734111
yuki0820@trust.ocn.ne.jp
NO
さいたま市立病院 Saitama municipal hospital
2012 | Year | 10 | Month | 10 | Day |
none
Unpublished
none
14
Compared to the slow titration group, the threshold maintenance group experienced significantly fewer allergic symptoms and anaphylaxis during treatment. Two of the eight patients in the threshold maintenance treatment group who continued treatment t were able to consume an egg without obvious allergic symptoms, and three of the remaining six patients were able to consume more egg antigen than the maintenance dose in the loading test 12 months later.
2022 | Year | 04 | Month | 18 | Day |
Patients with hen's egg allergy between 3 and15 years of age
The children were treated for one year after their caregivers were asked to choose between threshold maintenance therapy, in which the intake was increased daily from a small amount and continued at the immediately preceding intake when allergic symptoms were observed, and slow titration therapy, a conventional oral immunotherapy.
any allergic reaction
tolerance dose of hen's egg
serological change
Completed
2012 | Year | 08 | Month | 01 | Day |
2012 | Year | 06 | Month | 13 | Day |
2012 | Year | 08 | Month | 01 | Day |
2013 | Year | 12 | Month | 29 | Day |
2020 | Year | 12 | Month | 29 | Day |
2021 | Year | 03 | Month | 31 | Day |
2021 | Year | 08 | Month | 31 | Day |
2012 | Year | 10 | Month | 10 | Day |
2022 | Year | 04 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010653
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