Unique ID issued by UMIN | UMIN000009221 |
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Receipt number | R000010823 |
Scientific Title | Comparison of emergence and recovery time, and evaluation of oxygenation during one-lung ventilation with desflurane and propofol anesthesia in lung resection. |
Date of disclosure of the study information | 2012/10/30 |
Last modified on | 2023/05/09 18:40:45 |
Comparison of emergence and recovery time, and evaluation of oxygenation during one-lung ventilation with desflurane and propofol anesthesia in lung resection.
Comparison of emergence and recovery time, and evaluation of oxygenation during one-lung ventilation with desflurane and propofol anesthesia in lung resection.
Comparison of emergence and recovery time, and evaluation of oxygenation during one-lung ventilation with desflurane and propofol anesthesia in lung resection.
Comparison of emergence and recovery time, and evaluation of oxygenation during one-lung ventilation with desflurane and propofol anesthesia in lung resection.
Japan |
lung cancer
Chest surgery | Adult |
Malignancy
NO
Which is more adequate general anesthetic agents, desflurane or prropofol , for emergence and recovery time, and perioperative oxygenation in lung resection ?
Efficacy
- Blood samples will be collected Immediately after the induction of anesthesia in bilateral lung ventilation, 30 minutes after the start of OLV, one hour after the start of OLV and at the end of surgery in bilateral lung ventilation. Calculates the P / F ratio from the blood gas value.
Evaluation Criteria for Emergence:
-The time from the discontinuation of anesthesia to eye opening
-The time from the discontinuation of anesthesia to extubation.
-To confirm the effect of HPV by measuring changes in pulmonary blood flow. And also investigate the correlation between the attenuation of pulmonary blood flow and blood oxygen concentration.
- The time from the discontinuation of anesthesia to able to hold hand
- The time from the discontinuation of anesthesia to orientation(state place, state name, state the date of birth)
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Active
2
Treatment
Medicine |
A group which are used desflrane as general anesthetics.
A group which are used propofol as general anesthetics.
20 | years-old | <= |
75 | years-old | > |
Male and Female
-Patients agree to participate in the study
-Patients undergoing lung cancer surgery requiring OLV.
-ASA 1-2
Patients with any of the following will be excluded from lung cancer patients.
-NYHA Classification more than II
-Respiratory dysfunction VC or FEV1 is less than 50%
-Pulmonary hypertension with mean pulmonary arterial pressure more than 30mmHg
-Coagulation dysfunction
-The administration of steroids and immunosuppressive agents within 3 months prior to surgery
-Infection with active inflammation
-Pneumonectomy patients
-Cases of epidural anesthesia is contraindicated
80
1st name | Izumi |
Middle name | |
Last name | Kawagoe |
Juntendo University
Dept. of Anesthesiology and Pain Medicine
1138431
1-3, Hongo 3 cho-me, Bunkyo-ku,
03-3813-3111
ikawago@juntendo.ac.jp
1st name | Izumi |
Middle name | |
Last name | Kawagoe |
Juntendo University
Dept. of Anesthesiology and Pain Medicine
1138431
1-3, Hongo 3 cho-me, Bunkyo-ku,
03-3813-3111
ikawago@juntendo.ac.jp
Juntendo University, Faculty of Medicine
none
Self funding
IRB of Juntendo University hospital
Hongo3-1-3. Bunkyo-ku, Tokyo
0358021584
chiken@juntendo.ac.jp
NO
2012 | Year | 10 | Month | 30 | Day |
none
Published
https://tcr.amegroups.com/article/view/62230/html
160
There was no significant difference between the groups in the time to awakening, extubation, or orientation. However, emergence agitation (EA) occurred more frequently in Group D than in Group P. Numbers of patients not achieving full scores in respiration and circulation components of the modified Aldrete score 5 min after extubation were more in Group D. More patients required antiemetics during postoperative 24 hours in Group D.
2023 | Year | 05 | Month | 09 | Day |
Included were the American Society of Anesthesiologists (ASA) physical status1 and patients aged between 20 and 75 years, who were scheduled for lung cancer surgery less extensive than pneumonectomy. Excluded were patients with any of the following disorders; severe cardiac disease corresponding to the New York Heart Association Classification more than 2, severe respiratory dysfunction defined as the percent predicted vital capacity or percent predicted forced expiratory volume in one second less than 50 %, pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg, active inflammation, a history of treatment with steroids or immunosuppressive agents within 3 months before surgery, severe cognitive impairment, interstitial pneumonia or any contraindication for epidural anesthesia. These exclusion criteria were based on the following assumptions, severe cardiac dysfunction, and severe pulmonary hypertension might affect propofol elimination through possible hepatic congestion, severe respiratory dysfunction might affect the elimination of desflurane via the lungs, and uses of steroids and /or immunosuppressive agents might affect postoperative courses such as developments of postoperative nausea and vomiting (PONV) and postoperative infection.
Eighty patients scheduled for lung cancer surgery between December 2013 and March 2014 in Juntendo University Hospital were enrolled. This was a parallel study, and the allocation ratio was 1:1. Patients were divided into the desflurane group (Group D, n=40) and the propofol group (Group P, n=40) in a randomized manner using the envelope method. The patients did not know the allocated group. After the participants gave written informed consent on the day before surgery, they were randomized into each group using the envelope method, in the registration sequence. Forty pairs of cards, indicating either "propofol" or "desflurane" and put in 40 pairs of envelopes sealed subsequently, had been prepared and shuffled by one anesthesiologist in advance immediately after approval by the IRB.
None
There was no significant difference between the groups in the time to awakening, extubation, or orientation. However, emergence agitation (EA) occurred more frequently in Group D than in Group P (20/40 vs. 4/40, P<0.001). Numbers of patients not achieving full scores in respiration and circulation components of the modified Aldrete score 5 min after extubation were more in Group D (4/40 vs. 0/40, P=0.040; and 8/40 vs. 2/40, P=0.043, respectively). More patients required antiemetics during postoperative 24 hours in Group D (15/40 vs. 7/40, P=0.045).
Completed
2012 | Year | 10 | Month | 16 | Day |
2012 | Year | 09 | Month | 15 | Day |
2012 | Year | 11 | Month | 01 | Day |
2019 | Year | 09 | Month | 15 | Day |
2012 | Year | 10 | Month | 30 | Day |
2023 | Year | 05 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000010823
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