UMIN-CTR Clinical Trial

BACK TOP
UMIN-CTR English Home Glossary (Simple) FAQ Search clinical trials

Name:
UMIN ID:

Recruitment status No longer recruiting
Unique ID issued by UMIN UMIN000009412
Receipt No. R000011058
Scientific Title Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Date of disclosure of the study information 2012/11/27
Last modified on 2021/09/23

* This page includes information on clinical trials registered in UMIN clinical trial registed system.
* We don't aim to advertise certain products or treatments


Basic information
Public title Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Acronym Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Scientific Title Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Scientific Title:Acronym Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Region
Japan

Condition
Condition lung cancer
Classification by specialty
Chest surgery Anesthesiology
Classification by malignancy Malignancy
Genomic information NO

Objectives
Narrative objectives1 To confirm the efficacy of desflurane in maintenance of anesthesia of thoracic surgery, compared with propofol
Basic objectives2 Efficacy
Basic objectives -Others
Trial characteristics_1 Confirmatory
Trial characteristics_2
Developmental phase Not applicable

Assessment
Primary outcomes lung collapse score
duration of surgery
Key secondary outcomes postoperative complication
life prognosis

Base
Study type Interventional

Study design
Basic design Parallel
Randomization Randomized
Randomization unit Individual
Blinding Open -but assessor(s) are blinded
Control Active
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment

Intervention
No. of arms 2
Purpose of intervention Treatment
Type of intervention
Medicine
Interventions/Control_1 To use 4-6 % of desflurane in maintenance of anesthesia of thoracic surgery during VATS lobectomy anesthesia
Interventions/Control_2 To use 2-4 mcg/ml of propofol in maintenance of anesthesia of thoracic surgery during VATS lobectomy anesthesia
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10

Eligibility
Age-lower limit
20 years-old <=
Age-upper limit
75 years-old >=
Gender Male and Female
Key inclusion criteria patients who are indicated to VATS lobectomy, and age 20-65 years, American Society of Anesthesiologists physical status class 1-2, Hugh-Jones class 1-2, and New York Heart Association class 1-2
Key exclusion criteria history of cardiovascular or cerebrovascular disease and anticoagulant medication, severe chronic obstructive pulmonary disease, defined as %FEV1.0 < 50% of the predicted values; or severe restrictive lung disease, defined as %VC < 50% of the predicted values
Target sample size 60

Research contact person
Name of lead principal investigator
1st name Ryosuke
Middle name
Last name Kawanishi
Organization Tokushima University
Division name Department of Anesthesiology
Zip code 7708503
Address 18-15, 3-chome, Kuramoto-cho, Tokushima-shi, Tokushima, Japan
TEL 0886337181
Email Kawanishi.riyosuke@tokushima-u.ac.jp

Public contact
Name of contact person
1st name Ryosuke
Middle name
Last name Kawanishi
Organization Tokushima University
Division name Department of Anesthesiology
Zip code 770-8503
Address 2-50-1 Koramoto, Tokushima city, Tokushima, Japan
TEL 0886337181
Homepage URL
Email Kawanishi.riyosuke@tokushima-u.ac.jp

Sponsor
Institute Department of Anesthesiology, Tokushima university
Institute
Department

Funding Source
Organization Department of Anesthesiology, Tokushima University
Organization
Division
Category of Funding Organization Self funding
Nationality of Funding Organization

Other related organizations
Co-sponsor
Name of secondary funder(s)

IRB Contact (For public release)
Organization Clinical Research Review Board of Tokushima University
Address 2-50-1 Kuramoto, Tokushima city, Tokushikma, Japan
Tel 0886337958
Email brinshoshienk@tokushima-u.ac.jp

Secondary IDs
Secondary IDs NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW

Institutions
Institutions

Other administrative information
Date of disclosure of the study information
2012 Year 11 Month 27 Day

Related information
URL releasing protocol
Publication of results Unpublished

Result
URL related to results and publications
Number of participants that the trial has enrolled 60
Results In VATS lobectomy, desflurane was superior to propofol in lung collapse during one-lung ventilation and shortening the operation time.
Postoperative complications were also better with desflurane.
The prognosis of life and recurrence was not worse with desflurane than with propofol.
Results date posted
2021 Year 09 Month 23 Day
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description

Progress
Recruitment status No longer recruiting
Date of protocol fixation
2012 Year 10 Month 30 Day
Date of IRB
2012 Year 12 Month 21 Day
Anticipated trial start date
2013 Year 01 Month 01 Day
Last follow-up date
2022 Year 08 Month 30 Day
Date of closure to data entry
Date trial data considered complete
Date analysis concluded

Other
Other related information

Management information
Registered date
2012 Year 11 Month 27 Day
Last modified on
2021 Year 09 Month 23 Day


Link to view the page
URL(English) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011058

Research Plan
Registered date File name

Research case data specifications
Registered date File name

Research case data
Registered date File name


Contact us.