Unique ID issued by UMIN | UMIN000009412 |
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Receipt number | R000011058 |
Scientific Title | Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy |
Date of disclosure of the study information | 2012/11/27 |
Last modified on | 2023/06/09 13:10:27 |
Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Comparison of the effects of propofol and desflurane on lung collapse and operative time during VATS lobectomy
Japan |
lung cancer
Chest surgery | Anesthesiology |
Malignancy
NO
To confirm the efficacy of desflurane in maintenance of anesthesia of thoracic surgery, compared with propofol
Efficacy
Confirmatory
Not applicable
lung collapse score
duration of surgery
postoperative complication
life prognosis
Interventional
Parallel
Randomized
Individual
Open -but assessor(s) are blinded
Active
2
Treatment
Medicine |
To use 4-6 % of desflurane in maintenance of anesthesia of thoracic surgery during VATS lobectomy anesthesia
To use 2-4 mcg/ml of propofol in maintenance of anesthesia of thoracic surgery during VATS lobectomy anesthesia
20 | years-old | <= |
75 | years-old | >= |
Male and Female
patients who are indicated to VATS lobectomy, and age 20-65 years, American Society of Anesthesiologists physical status class 1-2, Hugh-Jones class 1-2, and New York Heart Association class 1-2
history of cardiovascular or cerebrovascular disease and anticoagulant medication, severe chronic obstructive pulmonary disease, defined as %FEV1.0 < 50% of the predicted values; or severe restrictive lung disease, defined as %VC < 50% of the predicted values
60
1st name | Ryosuke |
Middle name | |
Last name | Kawanishi |
Tokushima University
Department of Anesthesiology
7708503
18-15, 3-chome, Kuramoto-cho, Tokushima-shi, Tokushima, Japan
0886337181
Kawanishi.riyosuke@tokushima-u.ac.jp
1st name | Ryosuke |
Middle name | |
Last name | Kawanishi |
Tokushima University
Department of Anesthesiology
770-8503
2-50-1 Koramoto, Tokushima city, Tokushima, Japan
0886337181
Kawanishi.riyosuke@tokushima-u.ac.jp
Department of Anesthesiology, Tokushima university
Department of Anesthesiology, Tokushima University
Self funding
Clinical Research Review Board of Tokushima University
2-50-1 Kuramoto, Tokushima city, Tokushikma, Japan
0886337958
brinshoshienk@tokushima-u.ac.jp
NO
2012 | Year | 11 | Month | 27 | Day |
https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-022-01669-7
Published
https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-022-01669-7
60
In VATS lobectomy, desflurane was superior to propofol in lung collapse during one-lung ventilation and shortening the operation time.
Postoperative complications were also better with desflurane.
The prognosis of life and recurrence was not worse with desflurane than with propofol.
2021 | Year | 09 | Month | 23 | Day |
2022 | Year | 09 | Month | 29 | Day |
60 patients scheduled to undergo lobectomy by VATS in Tokushima University Hospital from January 2013 to July 2014
Lungs were inspected by thoracoscope at 10, 30, and 60 min after initiation of OLV. After surgery, the Lung Collapse Score, a composite of lung color and volume assessments, was assigned by two clinicians blinded to the anesthetic regimen. The primary outcome was operation time. The secondary outcome included the complication rate.
none
Lung collapse score, The primary outcome was operation time. The secondary outcome included the complication rate.
None at present
None at present
Completed
2012 | Year | 10 | Month | 30 | Day |
2012 | Year | 12 | Month | 21 | Day |
2013 | Year | 01 | Month | 01 | Day |
2022 | Year | 08 | Month | 30 | Day |
2012 | Year | 11 | Month | 27 | Day |
2023 | Year | 06 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011058
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