Unique ID issued by UMIN | UMIN000009532 |
---|---|
Receipt number | R000011193 |
Scientific Title | Pentraxin 3/sLOX-1 as a markar for early diagnosis of coronary artery abnormality in Kawasaki Disease |
Date of disclosure of the study information | 2013/01/01 |
Last modified on | 2021/06/21 10:05:24 |
Pentraxin 3/sLOX-1 as a markar for early diagnosis of coronary artery abnormality in Kawasaki Disease
PTX3/sLOX-1 in Kawasaki Disease with coronary artery abnormality
Pentraxin 3/sLOX-1 as a markar for early diagnosis of coronary artery abnormality in Kawasaki Disease
PTX3/sLOX-1 in Kawasaki Disease with coronary artery abnormality
Japan |
Kawasaki Disease
Cardiology | Pediatrics | Laboratory medicine |
Others
NO
To investigate a clinical significance of PTX3/sLOX-1 as a markar for early diagnosis of coronary artery abnormality in Kawasaki disease
Efficacy
Confirmatory
Pragmatic
Not applicable
high value of plasma PTX3/sLOX-1 in KD patients with coronary artery abnormality
not high value of plasma PTX3/sLOX-1 in KD patients without coronary artery abnormality at any sample point; onset, before IVIG therapy, after IVIG, near discharge, after discharge.
Observational
Not applicable |
16 | years-old | > |
Male and Female
Suspected of Kawasaki Disease KD
Principal symptoms
1. Fever persisting 5 days or more;
inclusive of cases in whom the fever
has subsided before the fifth day in
response to therapy;
2. Bilateral conjunctival congestion;
3. Changes of lips and oral cavity;
reddening of lips, strawberry tongue,
diffuse injection of oral and haryngeal
mucosa;
4. Polymorphous exanthema;
5. Changes of peripheral extremities;
6. Acute non-purulent cervical
lymphadenopathy.
At least five items of 6 should be satisfied for diagnosis of KD. However, patients with four items of the principal symptoms can be diagnosed with KD when coronary aneurysm or dilatation is recognized by 2-D echocardiography or coronary angiography.
The atypical; incomplete or suspected cases of KD is clincally important since they often develop coronary artery abnormalities. Approximately 10% of the total cases do not fulfil five of the six principal symptoms, in which other diseases can be excluded and KD is suspected. In some of these patients, coronary artery aneurysms have been confirmed. The prevalence of coronary artery abnormalities among those atypical patients was 5.5%.
If Kawasaki Disease has been excluded
100
1st name | Toshiyuki |
Middle name | |
Last name | Kitoh |
Aichi Medical University Hospital
Pediatrics
480-1195
Department of Pediatrics
0561-62-3311
tkitoh@aichi-med-u.ac.jp
1st name | Toshiyuki |
Middle name | |
Last name | Kitoh |
Aichi Medical University Hospital
Pediatrics
480-1195
1-1 Yazako Karimata, Nagakute, 480-1195, Japan
0561-62-3311
tkitoh@aichi-med-u.ac.jp
Ministry of Education
JSPS KAKENHI Grant Number 16K08422
Japanese Governmental office
Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo
Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
Toukai Foundation for Technology
Aichi Medical University
Department of Pediatrics
+81561623311
tkitoh@aichi-med-u.ac.jp
NO
愛知医科大学病院(愛知県)
2013 | Year | 01 | Month | 01 | Day |
https://link.springer.com/content/pdf/10.1007%2Fs00431-017-2979-8.pdf
Partially published
https://link.springer.com/content/pdf/10.1007%2Fs00431-017-2979-8.pdf
97
In total, 97 cases were registered. 22 case of incomplete KD were excluded from the outcome analysis.
2020 | Year | 06 | Month | 18 | Day |
2017 | Year | 10 | Month | 01 | Day |
Concluded 75 cases:age was betweeen 3 and 114 months; median 27 month,39 male and 26 female
Among the total of 75 cases concluded for statistical analyses, three had CAL and the remaining 72 cases did not (the non-CAL group).
nothing
PTX3 on admission in the KD
PTX3 on admission of the patients with coronary artery sequelae
intravenous immunoglobulin (IVIG) resistance
final doses of IVIG to stabilize the disease
freqenncy of KD-related CAL
PTX3 level correlated with the severity of disease
nothing
nothing
Main results already published
2012 | Year | 10 | Month | 26 | Day |
2013 | Year | 01 | Month | 16 | Day |
2013 | Year | 03 | Month | 01 | Day |
2017 | Year | 12 | Month | 31 | Day |
2017 | Year | 12 | Month | 31 | Day |
2018 | Year | 01 | Month | 31 | Day |
2019 | Year | 08 | Month | 06 | Day |
not open now
2012 | Year | 12 | Month | 12 | Day |
2021 | Year | 06 | Month | 21 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011193
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