Unique ID issued by UMIN | UMIN000010222 |
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Receipt number | R000011304 |
Scientific Title | The establishment of the effective treatment for hyperuricemia in hypertensive patient with hyperuricemia |
Date of disclosure of the study information | 2013/03/12 |
Last modified on | 2013/03/12 17:34:40 |
The establishment of the effective treatment for hyperuricemia in hypertensive patient with hyperuricemia
The treatment for hyperuricemia
The establishment of the effective treatment for hyperuricemia in hypertensive patient with hyperuricemia
The treatment for hyperuricemia
Japan |
hyperuricemia
Medicine in general |
Others
NO
The established of the effective treatment for hyperuricemia in hypertensive patient with hyperuricemia
Safety,Efficacy
serum uric acid, uric acid clearance, adverse event
blood pressure. renal function,
oxidant stress, endothelial function, renal artery resistance, inflammation
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
1.febuxostat40mg
2.febuxostat20mg+benzbromarone25mg
3.benzbromarone50mg
1.benzbromarone50mg
2.febuxostat20mg+benzbromarone25mg
3.febuxostat40mg
Not applicable |
Not applicable |
Male and Female
hypertensive patients with hyperuricemia, whose serum uric acid level >8 mg/dL on untreated or serum uric acid level >6 mg/dL in spite of taking UA lowering drugs over three months.
resistant hypertensive patient (SBP>=180mmHg or DBP>=110mmHg), heart failure patient (more than NYHA classification III or EF<=35%), severe renal damage patient (serum creatinine level >2 mg/dL), impaired liver function patient (AST or ALT>=100IU/ml), the patient with myocardial infarction, angina, and stroke within six months, an acute gouty attack patient, the patient with renal stone, the patient with taking mercaptopurine hydrate, azathioprine or warfarin, the patient with hypersensitivity to benzbromarone or febuxostat, patients to whom the doctor judged the participation in an examination to be unsuitable
20
1st name | |
Middle name | |
Last name | Yuhei Kawano |
National Cerebral and Cardiovascular Center
Division of Hypertension and Nephrology
Fujishirodai 5-7-1, Suita, Osaka
1st name | |
Middle name | |
Last name |
National Cerebral and Cardiovascular Center
Division of Hypertension and Nephrology
Fujishirodai 5-7-1, Suita, Osaka
National Cerebral and Cardiovascular Center
Japan cardiovascular research foundation scientific support enterprise
Non profit foundation
NO
2013 | Year | 03 | Month | 12 | Day |
Unpublished
Enrolling by invitation
2013 | Year | 03 | Month | 12 | Day |
2013 | Year | 03 | Month | 12 | Day |
2013 | Year | 03 | Month | 12 | Day |
2013 | Year | 03 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011304
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