Unique ID issued by UMIN | UMIN000009730 |
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Receipt number | R000011406 |
Scientific Title | The research of safety and liver dysfunction in IBD patients with HBV treated with immunomodulatory treatments. |
Date of disclosure of the study information | 2013/01/08 |
Last modified on | 2014/07/08 19:46:24 |
The research of safety and liver dysfunction in IBD patients with HBV treated with immunomodulatory treatments.
The research of safety and liver dysfunction in IBD patients with HBV treated with immunomodulatory treatments.
The research of safety and liver dysfunction in IBD patients with HBV treated with immunomodulatory treatments.
The research of safety and liver dysfunction in IBD patients with HBV treated with immunomodulatory treatments.
Japan |
Inflammatory bowel disease
Gastroenterology |
Others
NO
The aim of this study is to investigate the prevalence of HBV infection in IBD patients who have registered in our hospital from 2007 to 2012. We retrospectively evaluated the safety and risk factors for liver dysfunction in IBD patients with HBV infections with treated with immunomodulatory medications.
Safety
1. The prevalence of HBV infection
The number of patients with HBsAg-positive
The number of patients with HBsAb-positive and/or HBcAb-positive
2. The safety of medications
The prevalence of liver dysfunction* related to HBV and HBV reactivation
*Liver dysfunction is defined as an increase of 1.5-2-fold the baseline value ALT.
**Reactivation of HBV is defined as an increase of >2000IU/ml plus liver dysfunction (as above).
*/**Loras et al. Gut 2010
Observational
18 | years-old | <= |
80 | years-old | > |
Male and Female
Inclusion criteria:
UC and CD were diagnosed based on radiologic, endoscopic and histopathologic criteria.
None
4500
1st name | |
Middle name | |
Last name | Shiro Nakamura |
Hyogo College of Medicine
Department of Internal Medicine, Division of Lower Gastroenterology
1-1 Mukogawa-cho Nishinomiya-city Hyogo
0798-45-6663
shiro@hyo-med.ac.jp
1st name | |
Middle name | |
Last name | Yoko Yokoyama |
Hyogo College of Medicine
Department of Internal Medicine, Division of Lower Gastroenterology
Hyogo College of Medicine
0798-45-6111
yoko0502@hyo-med.ac.jp
Hyogo College of Medicine, Department of Internal Medicine, Division of Lower Gastroenterology
None
Other
NO
2013 | Year | 01 | Month | 08 | Day |
Unpublished
Open public recruiting
2007 | Year | 01 | Month | 04 | Day |
2007 | Year | 01 | Month | 04 | Day |
None
2013 | Year | 01 | Month | 08 | Day |
2014 | Year | 07 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011406
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