Unique ID issued by UMIN | UMIN000009841 |
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Receipt number | R000011533 |
Scientific Title | Exploratory Cross-sectional Study of Associations between Fatty Acid Metabolism Scintigraphy (123I-BMIPP test) in the Liver of Nonalcoholic Fatty Liver Disease (NAFLD) Patients and Serum Biomarkers and the Degree of Progression of NAFLD Pathology |
Date of disclosure of the study information | 2013/02/01 |
Last modified on | 2018/10/02 14:30:45 |
Exploratory Cross-sectional Study of Associations between Fatty Acid Metabolism Scintigraphy (123I-BMIPP test) in the Liver of Nonalcoholic Fatty Liver Disease (NAFLD) Patients and Serum Biomarkers and the Degree of Progression of NAFLD Pathology
Exploratory Cross-sectional Study of Associations between Fatty Acid Metabolism Scintigraphy (123I-BMIPP test) in the Liver of Nonalcoholic Fatty Liver Disease (NAFLD) Patients and Serum Biomarkers and the Degree of Progression of NAFLD Pathology
Exploratory Cross-sectional Study of Associations between Fatty Acid Metabolism Scintigraphy (123I-BMIPP test) in the Liver of Nonalcoholic Fatty Liver Disease (NAFLD) Patients and Serum Biomarkers and the Degree of Progression of NAFLD Pathology
Exploratory Cross-sectional Study of Associations between Fatty Acid Metabolism Scintigraphy (123I-BMIPP test) in the Liver of Nonalcoholic Fatty Liver Disease (NAFLD) Patients and Serum Biomarkers and the Degree of Progression of NAFLD Pathology
Japan |
nonalcoholic fatty liver disease
Hepato-biliary-pancreatic medicine | Endocrinology and Metabolism | Radiology |
Laboratory medicine | Adult |
Others
NO
We will explore associations among the degree of pathological progression in the liver of NAFLD patients, BMIPP uptake in the liver by fatty acid scintigraphy, serum markers and several factors associated with lipid metabolism in the liver.
Others
We will explore associations among the degree of pathological progression in the liver of NAFLD patients, BMIPP uptake in the liver by fatty acid scintigraphy, serum markers and several factors associated with lipid metabolism in the liver.
Exploratory
Pragmatic
We will conduct this study by performing fatty acid scintigraphy in NAFLD patients grouped according to the degree of histopathological progression in the liver and make comparisons between the degrees of BMIPP uptake in the various groups.
We will comprehensively analyze each factor involved in fatty acid metabolism in each group by using blood serum collected in the fasting state, after a meal, and during fatty acid scintigraphy, and liver tissue. Then we assess their relationships with the disease status.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Medicine | Device,equipment |
We will perform fatty acid scintigraphy (123I-BMIPP test).
20 | years-old | <= |
75 | years-old | > |
Male and Female
NAFLD patients
Patients with a pathological diagnosis of NAFLD based on a liver biopsy within the past 8 weeks
Patients from whom consent has been obtained to participate in this study, which has been approved by the ethics committee.
a. Patients who have any other liver disease, such as chronic hepatitis C, chronic hepatitis B (HBs-Ag-positive patients), autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, 1-antitrypsin deficiency, Wilson disease, or alcohol-related liver disease
b. Patients who have a serious hepatic dysfunction, liver failure (encephalopathy, ascites, ruptured varices, or hyperbilirubinemia)
c. Patients who have a serious renal dysfunction
d. Patients who have a serious cardiopulmonary dysfunction
e. Pregnant women, parturient women, breast-feeding women
60
1st name | |
Middle name | |
Last name | Yuichi Nozaki |
National Center for Global Health and Medicine
Department of Gastroenterology
1-21-1 Toyama, Shinjuku-ku, Tokyo
03-3202-7181
1st name | |
Middle name | |
Last name | Yuichi Nozaki |
National Center for Global Health and Medicine
Department of Gastroenterology
1-21-1 Toyama, Shinjuku-ku, Tokyo
03-3202-7181
National Center for Global Health and Medicine, Department of Gastroenterology
National Center for Global Health and Medicine
Other
Japan
Kochi University, Department of Gastroenterology
NO
国立国際医療研究センター(東京都)
2013 | Year | 02 | Month | 01 | Day |
Unpublished
Terminated
2012 | Year | 12 | Month | 26 | Day |
2013 | Year | 02 | Month | 01 | Day |
2013 | Year | 01 | Month | 22 | Day |
2018 | Year | 10 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011533
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