Unique ID issued by UMIN | UMIN000010190 |
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Receipt number | R000011932 |
Scientific Title | Randomized controlled trial to measure the Cp50incision of fentanyl with and without flurbiprofen axetil under propofol anesthesia |
Date of disclosure of the study information | 2013/03/07 |
Last modified on | 2013/03/07 20:25:15 |
Randomized controlled trial to measure the Cp50incision of fentanyl with and without flurbiprofen axetil under propofol anesthesia
Randomized controlled trial to measure the Cp50incision of fentanyl with and without flurbiprofen axetil under propofol anesthesia
Randomized controlled trial to measure the Cp50incision of fentanyl with and without flurbiprofen axetil under propofol anesthesia
Randomized controlled trial to measure the Cp50incision of fentanyl with and without flurbiprofen axetil under propofol anesthesia
Japan |
gynecologic laparoscopy
Anesthesiology |
Others
NO
We hypothesized that flurbiprofen axetil decreases the plasma fentanyl concentration required to immobilize 50% of patients during skin incision (Cp50incision) when compared with placebo under a target-controlled infusion (TCI) of propofol. We evaluated whether this finding had any significant influence on bispectral index (BIS), blood pressure (BP) and heart rate (HR) between the treatment groups.
PK,PD
fentanyl Cp50incision,BIS,BLOOD PRESSURE or HEART RATE
Interventional
Factorial
Randomized
Double blind -all involved are blinded
Placebo
2
Treatment
Medicine |
With flurbiprofen axetil
Without flurbiprofen axetil
20 | years-old | <= |
55 | years-old | >= |
Female
Women (American Society of Anesthesiologists physical status, I–II; 20–55 years of age) scheduled to undergo gynecologic laparoscopy were enrolled.
Patients with hepatic or renal disease, those with a body mass index (BMI) >30 kg.m-2, or those taking long-term analgesics were excluded.
70
1st name | |
Middle name | |
Last name | Mitsuharu Kodaka |
Tokyo Women's University
Anesthesiology
2-1-10 Nishi-ogu Arakawaku Tokyo
1st name | |
Middle name | |
Last name |
Saitama Medical University
Anesthesiology
http://www.saitama-med.ac.jp/kawagoe/05others/chiken/LocalSite/smc_iec/070._iec_ver.1.0
Saitama Medical University
Saitama Medical University
Other
NO
2013 | Year | 03 | Month | 07 | Day |
Unpublished
Completed
2005 | Year | 11 | Month | 29 | Day |
2005 | Year | 11 | Month | 29 | Day |
2013 | Year | 03 | Month | 07 | Day |
2013 | Year | 03 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011932
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