Unique ID issued by UMIN | UMIN000010596 |
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Receipt number | R000012290 |
Scientific Title | Randomized crossover trial comparing memantine or amantadine for Parkinson's disease with motor fluctuations in Juntendo |
Date of disclosure of the study information | 2013/05/01 |
Last modified on | 2015/10/25 10:05:01 |
Randomized crossover trial comparing memantine or amantadine for Parkinson's disease with motor fluctuations in Juntendo
MAP-J
Randomized crossover trial comparing memantine or amantadine for Parkinson's disease with motor fluctuations in Juntendo
MAP-J
Japan |
Parkinson's disease
Neurology |
Others
NO
For Parkinson's disease with motor fluctuations, compared the efficacy and safety of memantine and amantadine.
Safety,Efficacy
Confirmatory
Pragmatic
Improvement of dyskinesias
Changes in cognitive function score
Changes in REM sleep behavior disorder
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
Active
NO
NO
NO
Pseudo-randomization
2
Treatment
Medicine |
Memantine preceding arm
Titrate the memantine, administered for 3 months. And tapering memantine and amantadine titrate the dose for 3 months.
Amantadine preceding arm
Titrate the amantadine, administered for 3 months. And tapering amantadine and memantine titrate the dose for 3 months.
20 | years-old | <= |
Not applicable |
Male
1)dyskinesia with wearing off
2)Cognitive dysfunction(Moca-J point less than 26)
1)Patient has been administered amantadine or memantine already.
2)Patient dose needs to be changed during the study period cholinesterase inhibitors.
3)Patients scheduled to come into effect during the study period deep brain stimulation surgery(DBS).
4)Women and lactating women might be pregnant, are pregnant.
5)In addition, patients attending physician was deemed inappropriate.
40
1st name | |
Middle name | |
Last name | Nobutaka Hattori |
Juntendo University School of Medicine
Department of Neurology
2-1-1 Hongo Bunkyo Tokyo 113-8421 Japan
03-3813-3111
nhattori@juntendo.ac.jp
1st name | |
Middle name | |
Last name | Taku Hatano |
Juntendo University School of Medicine
Department of Neurology
2-1-1 Hongo Bunkyo Tokyo 113-8421 Japan
03-3813-3111
thatano@juntendo.ac.jp
Department of Neurology, Juntendo University School of Medicine
none
Self funding
NO
2013 | Year | 05 | Month | 01 | Day |
Unpublished
Terminated
2013 | Year | 03 | Month | 19 | Day |
2013 | Year | 05 | Month | 01 | Day |
2013 | Year | 04 | Month | 25 | Day |
2015 | Year | 10 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000012290
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