Unique ID issued by UMIN | UMIN000010792 |
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Receipt number | R000012630 |
Scientific Title | Association of postnatal neutral development and fetal movement |
Date of disclosure of the study information | 2013/05/23 |
Last modified on | 2020/05/28 09:47:51 |
Association of postnatal neutral development and fetal movement
Evaluation of neural development from fetal period
Association of postnatal neutral development and fetal movement
Evaluation of neural development from fetal period
Japan |
Autism spectrum
Obstetrics and Gynecology |
Others
NO
The object of this study is to discover new pathological factors which lead to onset of autism spectrum, observing fetal movement by ultrasonography.
Others
Discovering new pathological factors
Onset of autism spectrum at 3 years old
Observational
20 | years-old | <= |
Not applicable |
Female
In this study, following patients are recruited;
1) preterm labor
2) pregnancy induced hypertension syndrome (preeclampsia)
3) fetal growth restriction
Fetal anomaly is excluded in this study.
220
1st name | |
Middle name | |
Last name | Ikuo Konishi |
Kyoto University Graduate School of Medicine
Department of Gynecology and Obstetrics
54 Shogoinkawaharacho, Sakyo-ku, Kyoto, Japan
1st name | |
Middle name | |
Last name |
Kyoto University Graduate School of Medicine
Department of Gynecology and Obstetrics
Kyoto University Graduate School of Medicine
Japan Society for the Promotion of Science (JSPS)
NO
2013 | Year | 05 | Month | 23 | Day |
Unpublished
Enrolling by invitation
2013 | Year | 05 | Month | 09 | Day |
2015 | Year | 11 | Month | 10 | Day |
2013 | Year | 06 | Month | 01 | Day |
2030 | Year | 11 | Month | 21 | Day |
Fetal movement is observed by ultrasonography at 1st, 2nd, and 3rd trimester. Simultaneously, vaginal secretion is collected at each point. At delivery, umbilical blood and placenta are collected. If cesarean section is performed, amniotic fluid is collected just before the rupture of membrane. Approximately 1ml of neonatal blood is collected at the 4th day of birth when neonatal mass-screening blood test is performed.
In placenta, mRNA level of 11-beta HSD2 is quantified by quantitative RT-PCR. Cortisol level is assayed in umbilical and neonatal blood. Fetal fibronectin and fibronectin-EDA segment is quantified in vaginal secretion and amniotic fluid.
Neural development of the children is evaluated at 1, 3, 10 months, 1.5 years, and 3 years after birth.
2013 | Year | 05 | Month | 23 | Day |
2020 | Year | 05 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000012630
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